Osher Center for Integrative Medicine, University of California, 1545 Divisadero St,, San Francisco, CA 94115, USA.
BMC Complement Altern Med. 2014 Jul 1;14:212. doi: 10.1186/1472-6882-14-212.
Type 2 diabetes is a major health problem in many countries including India. Yoga may be an effective type 2 diabetes prevention strategy in India, particularly given its cultural familiarity.
This was a parallel, randomized controlled pilot study to collect feasibility and preliminary efficacy data on yoga for diabetes risk factors among people at high risk of diabetes. Primary outcomes included: changes in BMI, waist circumference, fasting blood glucose, postprandial blood glucose, insulin, insulin resistance, blood pressure, and cholesterol. We also looked at measures of psychological well-being including changes in depression, anxiety, positive and negative affect and perceived stress. Forty-one participants with elevated fasting blood glucose in Bangalore, India were randomized to either yoga (n = 21) or a walking control (n = 20). Participants were asked to either attend yoga classes or complete monitored walking 3-6 days per week for eight weeks. Randomization and allocation was performed using computer-generated random numbers and group assignments delivered in sealed, opaque envelopes generated by off-site study staff. Data were analyzed based on intention to treat.
This study was feasible in terms of recruitment, retention and adherence. In addition, yoga participants had significantly greater reductions in weight, waist circumference and BMI versus control (weight -0.8 ± 2.1 vs. 1.4 ± 3.6, p = 0.02; waist circumference -4.2 ± 4.8 vs. 0.7 ± 4.2, p < 0.01; BMI -0.2 ± 0.8 vs. 0.6 ± 1.6, p = 0.05). There were no between group differences in fasting blood glucose, postprandial blood glucose, insulin resistance or any other factors related to diabetes risk or psychological well-being. There were significant reductions in systolic and diastolic blood pressure, total cholesterol, anxiety, depression, negative affect and perceived stress in both the yoga intervention and walking control over the course of the study.
Among Indians with elevated fasting blood glucose, we found that participation in an 8-week yoga intervention was feasible and resulted in greater weight loss and reduction in waist circumference when compared to a walking control. Yoga offers a promising lifestyle intervention for decreasing weight-related type 2 diabetes risk factors and potentially increasing psychological well-being.
ClinicalTrials.gov Identified NCT00090506.
2 型糖尿病是包括印度在内的许多国家的主要健康问题。瑜伽可能是一种在印度预防 2 型糖尿病的有效策略，尤其是考虑到它在文化上的熟悉度。
这是一项平行、随机对照的初步研究，旨在收集瑜伽对糖尿病高危人群糖尿病风险因素的可行性和初步疗效数据。主要结果包括：体重指数（BMI）、腰围、空腹血糖、餐后血糖、胰岛素、胰岛素抵抗、血压和胆固醇的变化。我们还观察了心理幸福感的衡量指标，包括抑郁、焦虑、积极和消极影响以及感知压力的变化。在班加罗尔，41 名空腹血糖升高的参与者被随机分为瑜伽组（n=21）或步行对照组（n=20）。参与者被要求每周 3-6 天参加瑜伽课程或完成监测步行。随机分组和分配使用计算机生成的随机数进行，分组通过由场外研究人员生成的密封、不透明信封交付。数据基于意向治疗进行分析。
就招募、保留和依从性而言，这项研究是可行的。此外，与对照组相比，瑜伽组的体重、腰围和 BMI 显著降低（体重-0.8±2.1 与 1.4±3.6，p=0.02；腰围-4.2±4.8 与 0.7±4.2，p<0.01；BMI-0.2±0.8 与 0.6±1.6，p=0.05）。空腹血糖、餐后血糖、胰岛素抵抗或任何其他与糖尿病风险或心理幸福感相关的因素在两组之间均无差异。在瑜伽干预和步行对照组中，收缩压和舒张压、总胆固醇、焦虑、抑郁、消极影响和感知压力在研究过程中均显著降低。
在空腹血糖升高的印度人中，我们发现参加 8 周的瑜伽干预是可行的，与步行对照组相比，体重减轻更多，腰围减少。瑜伽为降低与体重相关的 2 型糖尿病风险因素和潜在增加心理幸福感提供了一种有前途的生活方式干预。
ClinicalTrials.gov 注册号 NCT00090506。
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