免疫缺陷病毒p24核心蛋白与小核糖核酸病毒VP2衣壳蛋白之间可能存在的同源性：对HIV p24抗原位点的预测。
A possible homology between immunodeficiency virus p24 core protein and picornaviral VP2 coat protein: prediction of HIV p24 antigenic sites.
作者信息
Argos P
机构信息
European Molecular Biology Laboratory, Heidelberg, FRG.
出版信息
EMBO J. 1989 Mar;8(3):779-85. doi: 10.1002/j.1460-2075.1989.tb03438.x.
Abstract
With the use of a sensitive sequence comparison algorithm, a homology has been suggested between the primary structures of simian immunodeficiency virus (SIV) p24 core protein and foot-and-mouth disease virus (FMD) VP2 coat protein. Since the FMD sequence is homologous to picornaviral VP2 sequences with known three-dimensional architecture and since the SIV p24 sequence can be convincingly aligned with that from human immunodeficiency virus (HIV), it was possible to predict an eight-stranded beta-barrel fold for the HIV core protein. From analogy with the known environments of the picornaviral coats, p24 sequence spans could be predicted as likely candidates for antibody attachment. These suggestions may be important for development of an AIDS vaccine.
摘要
通过使用一种灵敏的序列比较算法，有人提出猿猴免疫缺陷病毒（SIV）p24核心蛋白的一级结构与口蹄疫病毒（FMD）VP2衣壳蛋白之间存在同源性。由于FMD序列与具有已知三维结构的小核糖核酸病毒VP2序列同源，并且由于SIV p24序列可以令人信服地与人免疫缺陷病毒（HIV）的序列比对，因此有可能预测HIV核心蛋白的八链β桶折叠结构。根据与小核糖核酸病毒衣壳已知环境的类比，可以预测p24序列跨度可能是抗体附着的候选位点。这些推测对于艾滋病疫苗的开发可能具有重要意义。
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