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1
A possible homology between immunodeficiency virus p24 core protein and picornaviral VP2 coat protein: prediction of HIV p24 antigenic sites.免疫缺陷病毒p24核心蛋白与小核糖核酸病毒VP2衣壳蛋白之间可能存在的同源性：对HIV p24抗原位点的预测。
EMBO J. 1989 Mar;8(3):779-85. doi: 10.1002/j.1460-2075.1989.tb03438.x.
2
Conserved immunogenic region of a major core protein (p24) of human and simian immunodeficiency viruses.人类和猿猴免疫缺陷病毒主要核心蛋白（p24）的保守免疫原性区域。
AIDS Res Hum Retroviruses. 1988 Dec;4(6):409-17. doi: 10.1089/aid.1988.4.409.
3
Monoclonal antibodies against human immunodeficiency virus (HIV) type 2 core proteins: cross-reactivity with HIV type 1 and simian immunodeficiency virus.抗人免疫缺陷病毒2型核心蛋白的单克隆抗体：与1型人类免疫缺陷病毒和猴免疫缺陷病毒的交叉反应性
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6939-43. doi: 10.1073/pnas.85.18.6939.
4
Use of TrpE/Gag fusion proteins to characterize immunoreactive domains on the human immunodeficiency virus type 1 core protein.使用色氨酸合成酶E/群特异性抗原融合蛋白来鉴定1型人类免疫缺陷病毒核心蛋白上的免疫反应结构域。
J Virol. 1989 Sep;63(9):4064-8. doi: 10.1128/JVI.63.9.4064-4068.1989.
5
Highly conserved epitope domain in major core protein p24 is structurally similar among human, simian and feline immunodeficiency viruses.主要核心蛋白p24中高度保守的表位结构域在人类、猿猴和猫免疫缺陷病毒中在结构上相似。
J Gen Virol. 1992 Sep;73 ( Pt 9):2445-50. doi: 10.1099/0022-1317-73-9-2445.
6
Conserved epitopes on HIV-1, FIV and SIV p24 proteins are recognized by HIV-1 infected subjects.HIV-1感染个体可识别HIV-1、猫免疫缺陷病毒（FIV）和猴免疫缺陷病毒（SIV）p24蛋白上的保守表位。
Hum Vaccin Immunother. 2015;11(6):1540-56. doi: 10.1080/21645515.2015.1026500.
7
Biochemical and immunological analysis of human immunodeficiency virus gag gene products p17 and p24.人类免疫缺陷病毒gag基因产物p17和p24的生化与免疫学分析
J Virol. 1988 Mar;62(3):795-801. doi: 10.1128/JVI.62.3.795-801.1988.
8
Neutralizing monoclonal antibody against a external envelope glycoprotein (gp110) of SIVmac251.针对猴免疫缺陷病毒（SIVmac251）外膜糖蛋白（gp110）的中和性单克隆抗体。
AIDS Res Hum Retroviruses. 1995 Apr;11(4):501-8. doi: 10.1089/aid.1995.11.501.
9
Antiviral agents targeted to interact with viral capsid proteins and a possible application to human immunodeficiency virus.靶向与病毒衣壳蛋白相互作用的抗病毒药物及其在人类免疫缺陷病毒中的可能应用。
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4625-7. doi: 10.1073/pnas.85.13.4625.
10
Epitope mapping of monoclonal antibodies against human immunodeficiency virus type 1 structural proteins by using peptides.利用肽段对针对人类免疫缺陷病毒1型结构蛋白的单克隆抗体进行表位作图。
J Virol. 1989 Aug;63(8):3525-8. doi: 10.1128/JVI.63.8.3525-3528.1989.

引用本文的文献

1
Divergent evolution may link human immunodeficiency virus GP41 to human CD4.趋异进化可能将人类免疫缺陷病毒糖蛋白41与人类CD4联系起来。
J Mol Evol. 1993 May;36(5):448-57. doi: 10.1007/BF02406721.
2
Assembly-defective point mutants of the human immunodeficiency virus type 1 Gag precursor phenotypically expressed in recombinant baculovirus-infected cells.在重组杆状病毒感染细胞中表型表达的人类免疫缺陷病毒1型Gag前体的组装缺陷型点突变体。
J Virol. 1993 May;67(5):2787-98. doi: 10.1128/JVI.67.5.2787-2798.1993.
3
Phenotypic characterization of insertion mutants of the human immunodeficiency virus type 1 Gag precursor expressed in recombinant baculovirus-infected cells.在重组杆状病毒感染细胞中表达的人类免疫缺陷病毒1型Gag前体插入突变体的表型特征
J Virol. 1994 Jan;68(1):111-22. doi: 10.1128/JVI.68.1.111-122.1994.
4
Sequence requirements for encapsidation of deletion mutants and chimeras of human immunodeficiency virus type 1 Gag precursor into retrovirus-like particles.1型人类免疫缺陷病毒Gag前体的缺失突变体和嵌合体包装到逆转录病毒样颗粒中的序列要求。
J Virol. 1995 Apr;69(4):2366-77. doi: 10.1128/JVI.69.4.2366-2377.1995.
5
Preparation and crystallization of a human immunodeficiency virus p24-Fab complex.人免疫缺陷病毒p24-Fab复合物的制备与结晶
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9980-4. doi: 10.1073/pnas.87.24.9980.
6
Characterization of antibodies reacting with HIV gag proteins occasionally found in the serum of non-infected subjects.对在未感染个体血清中偶尔发现的与HIV gag蛋白反应的抗体的特性研究。
Clin Exp Immunol. 1991 Aug;85(2):219-23. doi: 10.1111/j.1365-2249.1991.tb05708.x.
7
Characterization of the antigenic domains of the major core protein (p26) of equine infectious anemia virus.马传染性贫血病毒主要核心蛋白（p26）抗原结构域的鉴定
J Virol. 1991 Feb;65(2):1007-12. doi: 10.1128/JVI.65.2.1007-1012.1991.
8
Linear B-cell epitopes of the major core protein of human immunodeficiency virus types 1 and 2.1型和2型人类免疫缺陷病毒主要核心蛋白的线性B细胞表位
J Virol. 1990 Sep;64(9):4258-63. doi: 10.1128/JVI.64.9.4258-4263.1990.
9
Assembly of recombinant human immunodeficiency virus type 1 capsid protein in vitro.重组人免疫缺陷病毒1型衣壳蛋白的体外组装
J Virol. 1992 Aug;66(8):4874-83. doi: 10.1128/JVI.66.8.4874-4883.1992.
10
Molecular mimicry and autoantigens in connective tissue diseases.结缔组织病中的分子模拟与自身抗原
Mol Biol Rep. 1992 Jun;16(3):139-47. doi: 10.1007/BF00464701.

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Protein secondary structure. Studies on the limits of prediction accuracy.蛋白质二级结构。预测准确性的极限研究。
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2
Establishing homologies in protein sequences.确定蛋白质序列中的同源性。
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The nucleotide and deduced amino acid sequences of the encephalomyocarditis viral polyprotein coding region.脑心肌炎病毒多聚蛋白编码区的核苷酸序列及推导的氨基酸序列。
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The complete nucleotide sequence of the RNA coding for the primary translation product of foot and mouth disease virus.口蹄疫病毒初级翻译产物编码RNA的完整核苷酸序列。
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Nucleotide sequence of Rous sarcoma virus.劳氏肉瘤病毒的核苷酸序列。
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Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis.猿猴肉瘤病毒基因组的核苷酸序列：证明其获得的细胞序列编码转化基因产物p28sis。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):731-5. doi: 10.1073/pnas.80.3.731.
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Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome.脊髓灰质炎病毒cDNA的分子克隆及病毒基因组完整核苷酸序列的测定。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4887-91. doi: 10.1073/pnas.78.8.4887.
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The complete nucleotide sequence of a common cold virus: human rhinovirus 14.一种普通感冒病毒——人鼻病毒14型的完整核苷酸序列。
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Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins.人类免疫缺陷病毒（HIV）的精细结构及结构蛋白的免疫定位
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免疫缺陷病毒p24核心蛋白与小核糖核酸病毒VP2衣壳蛋白之间可能存在的同源性：对HIV p24抗原位点的预测。

A possible homology between immunodeficiency virus p24 core protein and picornaviral VP2 coat protein: prediction of HIV p24 antigenic sites.

作者信息

Argos P

机构信息

European Molecular Biology Laboratory, Heidelberg, FRG.

出版信息

EMBO J. 1989 Mar;8(3):779-85. doi: 10.1002/j.1460-2075.1989.tb03438.x.

DOI:10.1002/j.1460-2075.1989.tb03438.x
PMID:2498082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC400874/
Abstract

With the use of a sensitive sequence comparison algorithm, a homology has been suggested between the primary structures of simian immunodeficiency virus (SIV) p24 core protein and foot-and-mouth disease virus (FMD) VP2 coat protein. Since the FMD sequence is homologous to picornaviral VP2 sequences with known three-dimensional architecture and since the SIV p24 sequence can be convincingly aligned with that from human immunodeficiency virus (HIV), it was possible to predict an eight-stranded beta-barrel fold for the HIV core protein. From analogy with the known environments of the picornaviral coats, p24 sequence spans could be predicted as likely candidates for antibody attachment. These suggestions may be important for development of an AIDS vaccine.

摘要

通过使用一种灵敏的序列比较算法，有人提出猿猴免疫缺陷病毒（SIV）p24核心蛋白的一级结构与口蹄疫病毒（FMD）VP2衣壳蛋白之间存在同源性。由于FMD序列与具有已知三维结构的小核糖核酸病毒VP2序列同源，并且由于SIV p24序列可以令人信服地与人免疫缺陷病毒（HIV）的序列比对，因此有可能预测HIV核心蛋白的八链β桶折叠结构。根据与小核糖核酸病毒衣壳已知环境的类比，可以预测p24序列跨度可能是抗体附着的候选位点。这些推测对于艾滋病疫苗的开发可能具有重要意义。