一种普通感冒病毒——人鼻病毒14型的完整核苷酸序列。
The complete nucleotide sequence of a common cold virus: human rhinovirus 14.
作者信息
Stanway G, Hughes P J, Mountford R C, Minor P D, Almond J W
出版信息
Nucleic Acids Res. 1984 Oct 25;12(20):7859-75. doi: 10.1093/nar/12.20.7859.
Abstract
The complete nucleotide sequence of the single-stranded RNA genome of human rhinovirus 14, one of the causative agents of the common cold, has been determined from cDNA cloned in E. coli. The genome is typical of the picornaviridae family, comprising a 5' non-coding region of 624 nucleotides, a long open reading frame of 6537 nucleotides (90.8% of the genome) and a 3' non-coding region of 47 nucleotides. Comparison of the nucleotide sequence and the predicted amino acid sequence with those of the polioviruses reveals a surprising degree of homology which may allow recognition of regions of antigenic importance and prediction of the virus polyprotein cleavage sites. The results presented here imply a closer genetic relationship between the rhinovirus and enterovirus genera than previously suspected.
摘要
人鼻病毒14是普通感冒的病原体之一，其单链RNA基因组的完整核苷酸序列已通过克隆于大肠杆菌中的cDNA测定。该基因组是小核糖核酸病毒科的典型代表，由624个核苷酸的5'非编码区、6537个核苷酸的长开放阅读框（占基因组的90.8%）和47个核苷酸的3'非编码区组成。将该核苷酸序列和预测的氨基酸序列与脊髓灰质炎病毒的序列进行比较，发现了惊人程度的同源性，这可能有助于识别具有抗原重要性的区域并预测病毒多聚蛋白的切割位点。此处呈现的结果表明，鼻病毒属和肠道病毒属之间的遗传关系比以前认为的更为密切。
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