Nishimura M, Nakada H, Nakajima H, Hori Y, Ezaki M, Goto T, Okuhara M
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
J Antibiot (Tokyo). 1989 Apr;42(4):542-8. doi: 10.7164/antibiotics.42.542.
A new antitumor antibiotic, FR900840, was isolated from a culture broth of Streptomyces strain No. 8727 as a pale yellowish prism and the molecular formula was determined to be C7H11N3O5. The antibiotic exhibited prominent antitumor effects on human tumor cell lines both in vitro and in vivo.
一种新的抗肿瘤抗生素FR900840从链霉菌8727号菌株的培养液中分离出来,呈淡黄色棱柱体,其分子式确定为C7H11N3O5。该抗生素在体外和体内对人肿瘤细胞系均表现出显著的抗肿瘤作用。