Chu Hannah X, Arumugam Thiruma V, Gelderblom Mathias, Magnus Tim, Drummond Grant R, Sobey Christopher G
Department of Pharmacology, Vascular Biology and Immunopharmacology Group, Monash University, Clayton, Victoria, Australia.
Department of Physiology, Yong Loo Lin School Medicine, National University of Singapore, Singapore, Singapore.
J Cereb Blood Flow Metab. 2014 Sep;34(9):1425-9. doi: 10.1038/jcbfm.2014.120. Epub 2014 Jul 2.
CC chemokine receptor 2 (CCR2) plays important roles in extravasation and transmigration of monocytes under inflammatory conditions. CCR2 and its ligands have been extensively studied in a range of inflammatory diseases in the central nervous system (CNS), including multiple sclerosis, Alzheimer's disease and ischemic stroke. This brief review summarizes our current understanding of the physiologic and pathologic roles of CCR2, focusing on its involvement in CNS inflammatory diseases. There appears to be a rationale for exploring therapies involving CCR2 inhibition in multiple sclerosis and ischemic stroke, but there is also evidence for immunomodulatory and protective effects of CCR2 activity during CNS inflammation. The critical balance between protective and detrimental roles of CCR2-dependent recruitment of leukocytes must therefore be carefully examined to guide safe and effective development of any therapies involving CCR2 modulation.
CC趋化因子受体2（CCR2）在炎症条件下单核细胞的外渗和迁移中发挥重要作用。CCR2及其配体已在中枢神经系统（CNS）的一系列炎症性疾病中得到广泛研究，包括多发性硬化症、阿尔茨海默病和缺血性中风。本简要综述总结了我们目前对CCR2生理和病理作用的理解，重点关注其在中枢神经系统炎症性疾病中的作用。在多发性硬化症和缺血性中风中探索涉及CCR2抑制的疗法似乎有一定道理，但也有证据表明CCR2活性在中枢神经系统炎症期间具有免疫调节和保护作用。因此，必须仔细研究CCR2依赖性白细胞募集的保护作用和有害作用之间的关键平衡，以指导任何涉及CCR2调节的疗法的安全有效开发。
