Cardiovascular Translational Research Center, Department of Internal Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ 85004, USA.
Department of Cardiovascular Medicine, Physiology and Biomedical Engineering, Center for Regenerative Biotherapeutics, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.
Int J Mol Sci. 2024 Aug 13;25(16):8794. doi: 10.3390/ijms25168794.
Aging is a prominent risk factor for numerous chronic diseases. Understanding the shared mechanisms of aging can aid in pinpointing therapeutic targets for age-related disorders. Chronic inflammation has emerged as a pivotal mediator of aging and a determinant in various age-related chronic conditions. Recent findings indicate that C-C motif chemokine ligand 2 and receptor 2 (CCL2-CCR2) signaling, an important physiological modulator in innate immune response and inflammatory defense, plays a crucial role in aging-related disorders and is increasingly recognized as a promising therapeutic target, highlighting its significance. This review summarizes recent advances in the investigation of CCL2-CCR2 signaling in cardiovascular and neural aging, as well as in various aging-related disorders. It also explores the underlying mechanisms and therapeutic potentials in these contexts. These insights aim to deepen our understanding of aging pathophysiology and the development of aging-related diseases.
衰老是许多慢性疾病的突出危险因素。了解衰老的共同机制有助于确定与年龄相关的疾病的治疗靶点。慢性炎症已成为衰老的关键介质，也是各种与年龄相关的慢性疾病的决定因素。最近的研究结果表明，C-C 基序趋化因子配体 2 和受体 2（CCL2-CCR2）信号转导作为先天免疫反应和炎症防御中的重要生理调节剂，在与衰老相关的疾病中起着至关重要的作用，并且越来越被认为是一个有前途的治疗靶点，凸显了其重要性。本综述总结了 CCL2-CCR2 信号在心血管和神经衰老以及各种与年龄相关的疾病中的研究进展。它还探讨了这些情况下的潜在机制和治疗潜力。这些见解旨在加深我们对衰老病理生理学和与衰老相关疾病发展的理解。
