通过肽功能化脂质体载体靶向脑内皮细胞用于氙气超高 CEST MRI。
Brain endothelial cell targeting via a peptide-functionalized liposomal carrier for xenon hyper-CEST MRI.
机构信息
ERC Project BiosensorImaging, Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
出版信息
Adv Healthc Mater. 2015 Jan 7;4(1):40-5. doi: 10.1002/adhm.201400224. Epub 2014 Jul 1.
PMID:24985966
Abstract
A nanoparticulate carrier system is used to efficiently deliver a contrast agent for highly sensitive xenon Hyper-CEST MRI. The carrier system not only improves the biocompatibility and solubility of the contrast agent, it also allows selective cell targeting as demonstrated by the discrimination of human brain capillary and aortic endothelial cells.
摘要
一种纳米颗粒载体系统被用于高效传递对比剂，以实现超高灵敏度氙气 Hyper-CEST MRI。该载体系统不仅提高了对比剂的生物相容性和溶解度，还可以实现选择性细胞靶向，如对人脑毛细血管和主动脉内皮细胞的区分所示。
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