Mavropoulou Antonia, Gnudi Giacomo, Grandi Giulio, Volta Antonella, Kramer Laura H, Quintavalla Cecilia
Department of Veterinary Sciences, University of Parma, Via del Taglio 10, Parma 43126, Italy.
Department of Veterinary Sciences, University of Parma, Via del Taglio 10, Parma 43126, Italy.
Vet Parasitol. 2014 Sep 15;205(1-2):211-5. doi: 10.1016/j.vetpar.2014.06.014. Epub 2014 Jun 17.
This study shows that a combination of doxycycline (10mg/kg/sid for 30 days) and ivermectin (6 μg/kg/every 15 days for 6 months) is well tolerated for the treatment of canine heartworm disease (HWD). Monthly echocardiography showed that 84% of treated dogs either progressively improved parameters indicative of pulmonary hypertension or, following slight worsening, resolved all signs. Thoracic radiography showed the persistence of interstitial inflammation, even though also in this case, approximately 70% of the dogs steadily improved or worsened but then improved by the end of the study.
本研究表明，强力霉素（10mg/kg/每日一次，共30天）和伊维菌素（6μg/kg/每15天一次，共6个月）联合使用治疗犬心丝虫病（HWD）耐受性良好。每月进行的超声心动图检查显示，84%接受治疗的犬，其指示肺动脉高压的参数要么逐渐改善，要么在略有恶化后所有症状均消失。胸部X线摄影显示间质性炎症持续存在，即便如此，在这种情况下，约70%的犬病情稳步改善或恶化，但在研究结束时病情好转。
