Wang Yu-Zhou, Wu Kun-Peng, Wu Ai-Bing, Yang Zhi-Cheng, Li Jin-Mei, Mo Yan-Li, Xu Meng, Wu Bin, Yang Zhi-Xiong
Cancer Center, Affiliated Hospital of Guangdong Medical College, No. 57 People's Avenue South, Zhanjiang, 524002, Guangdong, People's Republic of China.
Tumour Biol. 2014 Oct;35(10):9815-21. doi: 10.1007/s13277-014-2237-x. Epub 2014 Jul 2.
Matrix metalloproteinase-14 (MMP-14) has been demonstrated to play an important role in tumor progression. The aim of this study was to analyze the correlation between MMP-14 expression and clinicopathologic features and its prognostic significance in non-small cell lung cancer (NSCLC). Immunohistochemical staining for MMP-14 protein was performed in 104 patients with NSCLC. High levels of MMP-14 protein were positively correlated with the status of clinical stage (I-II vs. III-IV; P < 0.001), N classification (N0-N1 vs. N2-N3; P < 0.001), distant metastasis (no vs. yes; P = 0.014), and differentiated degree (high vs. low or undifferentiated; P = 0.001). The patients with higher MMP-14 expression of protein had shorter survival time than patients with low MMP-14 expression. Multivariate analysis indicated that the level of MMP-14 expression was an independent prognostic indicator (P < 0.001) for the survival of patients with NSCLC. In conclusion, MMP-14 is a potential unfavorable prognostic factor for patients with NSCLC.
基质金属蛋白酶-14（MMP-14）已被证明在肿瘤进展中起重要作用。本研究旨在分析MMP-14表达与非小细胞肺癌（NSCLC）临床病理特征之间的相关性及其预后意义。对104例NSCLC患者进行了MMP-14蛋白的免疫组织化学染色。MMP-14蛋白的高水平与临床分期状态（I-II期与III-IV期；P＜0.001）、N分级（N0-N1期与N2-N3期；P＜0.001）、远处转移（无转移与有转移；P = 0.014）以及分化程度（高分化与低分化或未分化；P = 0.001）呈正相关。MMP-14蛋白表达较高的患者比MMP-14表达较低的患者生存时间短。多因素分析表明，MMP-14表达水平是NSCLC患者生存的独立预后指标（P＜0.001）。总之，MMP-14是NSCLC患者潜在的不良预后因素。
