Philpott H, Nandurkar S, Royce S G, Thien F, Gibson P R
Department of Gastroenterology, Box Hill Hospital, Melbourne, Victoria, Australia; Department of Gastroenterology, The Alfred Hospital, Melbourne, Victoria, Australia.
Clin Exp Allergy. 2014 Aug;44(8):1012-9. doi: 10.1111/cea.12363.
Eosinophilic esophagitis (EoE) is a chronic antigen driven disease, whereby food and/or aeroallergens result in inflammation and luminal narrowing, and the clinical symptoms of dysphagia and food bolus obstruction events (FBOE). Established risk factors are male gender, Caucasian race and atopy. Increased risk amongst family members, and a single nucleotide polymorphism (SNP) in a gene coding thymic stromal lymphopoietin (TSLP) on the pseudoautosomal region of the X and Y chromosomes supports a genetic predisposition. Environmental factors including the timing and nature of food and aeroallergen exposure to the developing immune system may be important, whilst esophageal barrier function integrity and the influence of microbiota are worthy of future research.
嗜酸性粒细胞性食管炎（EoE）是一种慢性抗原驱动性疾病，食物和/或气传变应原可导致炎症和管腔狭窄，以及吞咽困难和食物团块梗阻事件（FBOE）的临床症状。已确定的风险因素包括男性、白种人和特应性。家庭成员患病风险增加，以及X和Y染色体假常染色体区域编码胸腺基质淋巴细胞生成素（TSLP）的基因中的单核苷酸多态性（SNP）支持遗传易感性。环境因素，包括食物和气传变应原暴露于发育中的免疫系统的时间和性质可能很重要，而食管屏障功能完整性和微生物群的影响值得未来研究。
