Abulawi Ahmad, Liu Jacqueline, Philip Shawn, Josephson Mathew, Abdelwahab Hala, Feustel Paul J, Batool Asra
Department of Internal Medicine, Albany Medical Center, Albany, New York.
Department of Gastroenterology and Hepatology, Albany Medical Center, Albany, New York.
Gastro Hep Adv. 2022 May 2;1(5):703-708. doi: 10.1016/j.gastha.2022.04.020. eCollection 2022.
Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease characterized by symptoms related to esophageal dysfunction and eosinophil-predominant inflammation. The aims of our study included (1) to assess esophageal motility patterns of EoE by topographic analysis of high-resolution manometry (HRM) and (2) to establish a relationship between symptoms of EoE and motility abnormalities seen on HRM.
A retrospective study in which all adult patients over 18 years of age with EoE diagnosed by endoscopy and histology and who underwent HRM were included in the study during the study period. Motility patterns in patients with EoE under HRM were analyzed. Data were presented as frequencies and percentages with inference by Pearson's chi-square test or Fisher's exact test.
Seven hundred patients diagnosed with EoE were noted, and of these, 38 patients had undergone esophageal HRM. Fifty-eight percent of these patients were noted to have an esophageal motility abnormality on HRM. Thirty-seven percent of the patients showed absent peristalsis with pan-esophageal pressurization but normal integrate relaxation pressure; 21% of the patients showed peristaltic dysfunction; and 42% of the patients had a normal HRM. Seventy-one percent of the patients with pan-esophageal pressurization presented with food impaction requiring endoscopy for disimpaction and esophageal dilation ( = .015).
The most common abnormality noted was aperistalsis with pan-esophageal pressurization. This abnormality correlated with the clinical presentation of bolus impaction requiring an endoscopic intervention ( = .015).
嗜酸性粒细胞性食管炎（EoE）是一种免疫介导的食管疾病，其特征为与食管功能障碍相关的症状以及以嗜酸性粒细胞为主的炎症。我们研究的目的包括：（1）通过高分辨率测压法（HRM）的地形分析评估EoE的食管动力模式；（2）确定EoE症状与HRM所见动力异常之间的关系。
一项回顾性研究，研究期间纳入了所有年龄超过18岁、经内镜和组织学诊断为EoE且接受了HRM检查的成年患者。分析了HRM检查下EoE患者的动力模式。数据以频率和百分比形式呈现，并通过Pearson卡方检验或Fisher精确检验进行推断。
共记录了700例诊断为EoE的患者，其中38例接受了食管HRM检查。这些患者中58%在HRM检查中发现有食管动力异常。37%的患者表现为蠕动消失伴全食管加压，但综合松弛压正常；21%的患者表现为蠕动功能障碍；42%的患者HRM检查正常。全食管加压的患者中有71%出现食物嵌塞，需要内镜检查以解除嵌塞并进行食管扩张（P = 0.015）。
最常见的异常是蠕动消失伴全食管加压。这种异常与需要内镜干预的团块嵌塞的临床表现相关（P = 0.015）。
