Cooper Philip J, Chico Martha E, Platts-Mills Thomas Ae, Rodrigues Laura C, Strachan David P, Barreto Mauricio L
Laboratorio de Investigaciones FEPIS, Quinindé, Esmeraldas Province, Ecuador, Institute of Infection and Immunity Research, Institute of Population Health Research, St George's University of London, London, UK, Centro de Investigación en Enfermedades Infecciosas, Escuela de Biología, Pontificia Universidad Católica del Ecuador, Quito, Ecuador,
Laboratorio de Investigaciones FEPIS, Quinindé, Esmeraldas Province, Ecuador.
Int J Epidemiol. 2015 Oct;44(5):1517-27. doi: 10.1093/ije/dyu128. Epub 2014 Jul 2.
The ECUAVIDA birth cohort is studying the impact of exposures to soil-transmitted helminth (STH) parasites and early-life microbial exposures on the development of atopy, allergic diseases and immune responses in childhood. A total of 2404 newborns were recruited between 2006 and 2009 in a public hospital serving the rural district of Quininde, Esmeraldas Province, in a tropical region of coastal Ecuador. Detailed measurements were done around the time of the birth, at 7 and 13 months and at 2 and 3 years, and data collection is ongoing at 5 and 8 years. Data being collected include questionnaires for: sociodemographic, lifestyle, psychosocial (at 4-6 years only) and dietary (at 6-7 years only) factors; childhood morbidity and clinical outcomes; stool samples for parasites; blood samples for DNA, measurements of vaccine responses and other measures of immune function/inflammation; and anthropometrics. Allergen skin prick test reactivity is done from 2 years and measures of airway function and inflammation at 8 years.
ECUAVIDA出生队列研究正在探究土壤传播的蠕虫（STH）寄生虫暴露和早期微生物暴露对儿童期特应性、过敏性疾病及免疫反应发展的影响。2006年至2009年期间，在厄瓜多尔沿海热带地区埃斯梅拉达斯省基宁德农村地区的一家公立医院招募了共计2404名新生儿。在出生时、7个月和13个月以及2岁和3岁左右进行了详细测量，目前正在收集5岁和8岁时的数据。正在收集的数据包括以下方面的问卷：社会人口统计学、生活方式、心理社会（仅在4至6岁时）和饮食（仅在6至7岁时）因素；儿童发病率和临床结果；寄生虫粪便样本；用于DNA检测、疫苗反应测量及其他免疫功能/炎症测量的血液样本；以及人体测量学数据。从2岁开始进行过敏原皮肤点刺试验反应性检测，并在8岁时测量气道功能和炎症指标。
