磷脂酶D1在癌症中的细胞及生理作用
Cellular and physiological roles for phospholipase D1 in cancer.
作者信息
Zhang Yi, Frohman Michael A
机构信息
Center for Developmental Genetics and the Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794.
Center for Developmental Genetics and the Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794.
出版信息
J Biol Chem. 2014 Aug 15;289(33):22567-22574. doi: 10.1074/jbc.R114.576876. Epub 2014 Jul 2.
Abstract
Phospholipase D enzymes have long been proposed to play multiple cell biological roles in cancer. With the generation of phospholipase D1 (PLD1)-deficient mice and the development of small molecule PLD-specific inhibitors, in vivo roles for PLD1 in cancer are now being defined, both in the tumor cells and in the tumor environment. We review here tools now used to explore in vivo roles for PLD1 in cancer and summarize recent findings regarding functions in angiogenesis and metastasis.
摘要
长期以来，人们一直认为磷脂酶D酶在癌症中发挥多种细胞生物学作用。随着磷脂酶D1（PLD1）基因敲除小鼠的产生以及小分子PLD特异性抑制剂的开发，现在正在确定PLD1在癌症中的体内作用，包括在肿瘤细胞和肿瘤环境中的作用。我们在此回顾目前用于探索PLD1在癌症中体内作用的工具，并总结有关血管生成和转移功能的最新发现。
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