Streit Laura, Brunaud Laurent, Vitale Nicolas, Ory Stéphane, Gasman Stéphane
Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Université de Strasbourg, F-67000 Strasbourg, France.
Département de Chirurgie Viscérale, Métabolique et Cancérologique (CVMC), Unité Médico-chirurgicale de Chirurgie Métabolique, Endocrinienne et Thyroïdienne (UMET), Unité Médico-chirurgicale de Chirurgie de L'obésité (UMCO), Université de Lorraine, CHRU NANCY, Hôpital Brabois Adultes, F-54511 Vandœuvre-lès-Nancy, France.
Cancers (Basel). 2020 Jul 10;12(7):1859. doi: 10.3390/cancers12071859.
Neuroendocrine tumors (NETs) belong to a heterogeneous group of neoplasms arising from hormone secreting cells. These tumors are often associated with a dysfunction of their secretory activity. Neuroendocrine secretion occurs through calcium-regulated exocytosis, a process that is tightly controlled by Rho GTPases family members. In this review, we compiled the numerous mutations and modification of expression levels of Rho GTPases or their regulators (Rho guanine nucleotide-exchange factors and Rho GTPase-activating proteins) that have been identified in NETs. We discussed how they might regulate neuroendocrine secretion.
神经内分泌肿瘤（NETs）属于一组起源于激素分泌细胞的异质性肿瘤。这些肿瘤通常与其分泌活性功能障碍有关。神经内分泌分泌通过钙调节的胞吐作用发生，这一过程受到Rho GTP酶家族成员的严格控制。在本综述中，我们汇总了在神经内分泌肿瘤中已鉴定出的Rho GTP酶或其调节因子（Rho鸟嘌呤核苷酸交换因子和Rho GTP酶激活蛋白）的众多突变和表达水平的改变。我们讨论了它们可能如何调节神经内分泌分泌。
