Gomez-Cambronero Julian, Carman George M
Department of Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, Ohio 45435 and.
Department of Food Science, Rutgers Center for Lipid Research, and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey 08901.
J Biol Chem. 2014 Aug 15;289(33):22554-22556. doi: 10.1074/jbc.R114.593137. Epub 2014 Jul 2.
Phospholipase D (PLD) signaling plays a critical role in cell growth and proliferation, vesicular trafficking, secretion, and endocytosis. At the cellular level, PLD and its reaction product, phosphatidate, interact with a large number of protein partners that are directly related to the actin cytoskeleton and cell migration. Cancer invasion and metastasis rely heavily on cellular motility, and as such, they have put PLD at center stage in cancer research. This minireview series highlights some of the molecular mechanisms that provide evidence for the emerging tumorigenic potential of PLD, the role of the microenvironment, and putative connections with inflammation. PLD represents a potential target for the rational development of therapeutics against cancer and other diseases.
磷脂酶D（PLD）信号传导在细胞生长与增殖、囊泡运输、分泌及内吞作用中发挥着关键作用。在细胞水平上，PLD及其反应产物磷脂酸与大量直接参与肌动蛋白细胞骨架及细胞迁移的蛋白质相互作用。癌症侵袭和转移严重依赖细胞运动性，因此，PLD成为癌症研究的核心。本系列小型综述着重介绍了一些分子机制，这些机制为PLD新出现的致癌潜能、微环境的作用以及与炎症的假定联系提供了证据。PLD是合理开发抗癌及其他疾病治疗药物的潜在靶点。
