龙血树属植物龙血树树脂的植物化学和抗葡萄球菌生物膜评估
Phytochemical and anti-staphylococcal biofilm assessment of Dracaena draco L. Spp. draco resin.
作者信息
Stefano V Di, Pitonzo R, Schillaci D
机构信息
Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Italy.
Centro Grandi Apparecchiature UniNetLab, University of Palermo, Italy.
出版信息
Pharmacogn Mag. 2014 Apr;10(Suppl 2):S434-40. doi: 10.4103/0973-1296.133300.
BACKGROUND
Dracaena draco L. ssp. draco is known as the "dragon's blood tree" and it is endemic from the Canary Islands and Morocco.
OBJECTIVE
Carry out phytochemical investigation of acetonic extracts of red resin obtained from the trunk of D. draco, to obtain to the isolation of the most abundant resin constituents, belonging to the class of flavonoids: flavans, along with homoisoflavans and homoisoflavanones.
MATERIALS AND METHODS
The structures of the isolated compounds were established by Nuclear Magnetic Resonance (NMR) and mass spectrometry data and comparison with literature data. The acetonic extract was evaluated for its anti-staphylococcal properties against two reference strains.
RESULTS
The acetonic extracts resulted inactive at the maximum tested concentration of 1000 μg/ml against free living forms of tested staphylococci, but they showed a very interesting activity in the prevention of a biofilm formation at a concentration equal to 200 μg/ml against S. aureus ATCC 25923.
背景
龙血树（Dracaena draco L. ssp. draco）被称为“龙血树”，是加那利群岛和摩洛哥特有的植物。
目的
对从龙血树树干中获得的红色树脂的丙酮提取物进行植物化学研究，以分离出最丰富的树脂成分，这些成分属于黄酮类：黄烷类，以及高异黄酮和高异黄酮酮。
材料与方法
通过核磁共振（NMR）和质谱数据以及与文献数据比较确定分离出的化合物的结构。评估丙酮提取物对两种参考菌株的抗葡萄球菌特性。
结果
丙酮提取物在最高测试浓度1000μg/ml时对测试葡萄球菌的自由生存形式无活性，但在浓度等于200μg/ml时对金黄色葡萄球菌ATCC 25923表现出非常有趣的预防生物膜形成的活性。
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