一种方便的对映选择性脱羧醛醇反应，用于使用β-酮酸获得手性α-羟基酯。
A convenient enantioselective decarboxylative aldol reaction to access chiral α-hydroxy esters using β-keto acids.
机构信息
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China ; Institute for Chemistry & Biomedical Sciences, Nanjing University, Nanjing, 210093, China.
出版信息
Beilstein J Org Chem. 2014 Apr 29;10:969-74. doi: 10.3762/bjoc.10.95. eCollection 2014.
We show a convenient decarboxylative aldol process using a scandium catalyst and a PYBOX ligand to generate a series of highly functionalized chiral α-hydroxy esters. The protocol tolerates a broad range of β-keto acids with inactivated aromatic and aliphatic α-keto esters. The possible mechanism is rationalized.
我们展示了一种使用钪催化剂和 PYBOX 配体的方便脱羧醛醇缩合反应，以生成一系列高度官能化的手性α-羟基酯。该方案可耐受广泛的具有失活芳香族和脂肪族α-酮酯的β-酮酸。对可能的机理进行了合理化。
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