手性铒催化β-酮酸对色酮的脱羧加成反应合成 3-羟基吲哚啉酮
Enantioselective synthesis of 3-hydroxy oxindoles by ytterbium-catalysed decarboxylative addition of β-ketoacids to isatins.
机构信息
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
出版信息
Org Biomol Chem. 2013 Oct 14;11(38):6456-9. doi: 10.1039/c3ob41460d. Epub 2013 Aug 27.
PMID:23979548
Abstract
A ytterbium(III)-indapybox catalysed enantioselective decarboxylative addition reaction of β-ketoacids to isatins is described. The biologically important 3-hydroxy oxindoles were obtained in high yields and excellent enantioselectivities.
摘要
描述了一种由镱（III）-吲哚并吡咯酮催化的β-酮酸对色酮的对映选择性脱羧加成反应。得到了具有生物重要性的 3-羟基氧吲哚，产率高，对映选择性优异。
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