1-[双（三氟甲基）膦]-1'-恶唑啉基二茂铁配体的合成及其在手性钯催化单取代烯丙基底物区域和对映选择性烯丙基烷基化反应中的应用。
Synthesis of 1-[bis(trifluoromethyl)phosphine]-1'-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China ; State Key Laboratory of Natural Medicines and Center of Drug Discovery, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.
Process Development and Manufacturing Department, Pharmaron (Beijing) Co. Ltd, 6 Taihe Road, BDA, Beijing, 100176, China.
出版信息
Beilstein J Org Chem. 2014 May 30;10:1261-6. doi: 10.3762/bjoc.10.126. eCollection 2014.
A class of novel, easily accessible and air-stable 1-[bis(trifluoromethyl)phosphine]-1'-oxazolinylferrocene ligands has been synthesized from ferrocene. It became apparent that these ligands can be used in the regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates in a highly efficient manner. Excellent regio- and enantioselectivity could be obtained for a wide range of substrates.
一类新型的、易于获得且空气稳定的 1-[双（三氟甲基）膦]-1'-恶唑啉基二茂铁配体已经从二茂铁合成。显然，这些配体可以在高度有效的方式中用于 Pd 催化的单取代烯丙基底物的区域和对映选择性烯丙基烷基化反应中。对于广泛的底物，可以获得优异的区域和对映选择性。
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