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PN-杂环膦配体的结构与合成

Architecture and synthesis of PN-heterocyclic phosphine ligands.

作者信息

Munzeiwa Wisdom A, Omondi Bernard, Nyamori Vincent O

机构信息

School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, Durban 4000, South Africa.

School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg Campus, Private Bag X01, Scottsville, Pietermaritzburg 3201, South Africa.

出版信息

Beilstein J Org Chem. 2020 Mar 12;16:362-383. doi: 10.3762/bjoc.16.35. eCollection 2020.

DOI:10.3762/bjoc.16.35
PMID:32256853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7082614/
Abstract

Diverse P,N-phosphine ligands reported to date have performed exceptionally well as auxiliary ligands in organometallic catalysis. Phosphines bearing 2-pyridyl moieties prominently feature in literature as compared to phosphines with five-membered N-heterocycles. This discussion seeks to paint a broad picture and consolidate different synthetic protocols and techniques for N-heterocyclic phosphine motifs. The introduction provides an account of P,N-phosphine ligands, and their structural and coordination benefits from combining heteroatoms with different basicity in one ligand. The body discusses the synthetic protocols which focus on P-C, P-N-bond formation, substrate and nucleophile types and different N-heterocycle construction strategies. Selected references are given in relation to the applications of the ligands.

摘要

迄今为止报道的各种P，N-膦配体在有机金属催化中作为辅助配体表现得非常出色。与带有五元N-杂环的膦相比，带有2-吡啶基部分的膦在文献中尤为突出。本讨论旨在描绘一幅广阔的图景，并整合用于N-杂环膦基序的不同合成方案和技术。引言部分介绍了P，N-膦配体，以及在一个配体中结合不同碱性杂原子所带来的结构和配位优势。正文部分讨论了合成方案，重点是P-C、P-N键的形成、底物和亲核试剂类型以及不同的N-杂环构建策略。还给出了与这些配体应用相关的参考文献。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36b/7082614/19af5d2bf681/Beilstein_J_Org_Chem-16-362-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36b/7082614/fa46c2236b94/Beilstein_J_Org_Chem-16-362-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36b/7082614/73c0eb81558c/Beilstein_J_Org_Chem-16-362-g018.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36b/7082614/b03c788220ac/Beilstein_J_Org_Chem-16-362-g021.jpg

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