埃塞俄比亚西南部吉马大学专科医院内科病房患者的药物相关问题
Drug-related problems among medical ward patients in Jimma university specialized hospital, Southwest Ethiopia.
作者信息
Tigabu Bereket Molla, Daba Daniel, Habte Belete
机构信息
Department of Clinical Pharmacy, Haramaya University, Ethiopia.
Department of Pharmacy, Jimma University, Jimma, Ethiopia.
出版信息
J Res Pharm Pract. 2014 Jan;3(1):1-5. doi: 10.4103/2279-042X.132702.
OBJECTIVE
The increasing number of available drugs and drug users, as well as more complex drug regimens led to more side effects and drug interactions and complicates follow-up. The objective of this study was to assess drug-related problems (DRPs) and associated factors in hospitalized patients.
METHODS
A hospital-based cross-sectional study design was employed. The study was conducted in Jimma University Specialized Hospital, Jimma, located in the south west of Addis Ababa. All patients who were admitted to the medical ward from February 2011 to March 2011 were included in the study. Data on sociodemographic variables, past medical history, drug history, current diagnosis, current medications, vital signs, and relevant laboratory data were collected using semi-structured questionnaire and data collection forms which were filling through patient interview and card review. Data were analyzed using SPSS version 16 for windows. Descriptive statistics, cross-tabs, Chi-square, and logistic regression were utilized.
FINDINGS
Out of 257 study participants, 189 (73.5%) had DRPs and a total of 316 DRPs were identified. From the six classes of DRPs studied, 103 (32.6%) cases related to untreated indication or need additional drug therapy, and 49 (15.5%) cases related to high medication dosage. Unnecessary drug therapy in 49 (15.5%) cases, low medication dosage in 44 (13.9%) cases, and ineffective drug therapy in 42 (13.3%) cases were the other classes of problems identified. Noncompliance in 31 (9.8%) cases was the least prevalent DRP. Independent factors which predicted the occurrence of DRPs in the study population were sex, age, polypharmacy, and clinically significant potential drug-drug interactions. The prevalence of DRPs was substantially high (73.5%).
CONCLUSION
Drug-related problems are common among medical ward patients. Indication-related problems, untreated indication and unnecessary drug therapy were the most common types of DRPs among patients of our medical ward.
目的
可用药物和药物使用者数量不断增加，以及药物治疗方案更加复杂，导致更多副作用和药物相互作用，并使随访复杂化。本研究的目的是评估住院患者的药物相关问题（DRP）及相关因素。
方法
采用基于医院的横断面研究设计。研究在位于亚的斯亚贝巴西南部的吉马大学专科医院进行。纳入2011年2月至2011年3月入住内科病房的所有患者。使用半结构化问卷和数据收集表收集社会人口统计学变量、既往病史、用药史、当前诊断、当前用药、生命体征和相关实验室数据，通过患者访谈和病历审查进行填写。使用Windows版SPSS 16对数据进行分析。采用描述性统计、交叉表、卡方检验和逻辑回归分析。
结果
在257名研究参与者中，189名（73.5%）存在DRP，共识别出316个DRP。在所研究的六类DRP中，103例（32.6%）与未治疗的适应症或需要额外药物治疗有关，49例（15.5%）与药物高剂量有关。49例（15.5%）为不必要的药物治疗，44例（13.9%）为药物低剂量，42例（13.3%）为无效药物治疗，是识别出的其他问题类别。31例（9.8%）为用药依从性差，是最不常见的DRP。预测研究人群中DRP发生的独立因素为性别、年龄、多种药物联合使用以及具有临床意义的潜在药物相互作用。DRP的患病率相当高（73.5%）。
结论
药物相关问题在内科病房患者中很常见。适应症相关问题、未治疗的适应症和不必要的药物治疗是我们内科病房患者中最常见的DRP类型。
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