Department of Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan.
Int J Clin Pharm. 2011 Jun;33(3):501-11. doi: 10.1007/s11096-011-9497-y. Epub 2011 Mar 26.
The aim of this study was to identify the prevalence and characteristics of treatment related problems (TRPs) in hospitalized internal medicine patients in Jordan as well as to identify diseases and drugs associated with each specific TRP. We have also aimed at investigating physicians' acceptance of recommendations made by clinical pharmacist and to identify the outcomes of pharmacist interventions.
Internal medicine department of a general hospital in Jordan.
We have utilized a systematic, prospective, bedside, comprehensive clinical assessment approach that allowed us to effectively identify, communicate and follow up TRPs.
prevalence and nature of identified TRPs, clinical significance of TRPs, associated diseases and drugs and clinical outcomes of clinical pharmacist interventions.
402 patients were included in the study. The average number of the identified TRPs was 9.35. Fifty-three percent of identified TRPs were classified as major and 28% were classified as moderate. Ninety-one percent of the recommendations were accepted by physicians. Efficacy related problems were the most common TRP category followed by safety related problems and indication related problems. Sixty-four percent of the TRPs were resolved or prevented through the clinical pharmacist intervention.
We have found that prevalence of TRPs is substantially high among patients hospitalized at the internal medicine department. TRPs related to Dosage regimens, untreated conditions, patient monitoring, drug interactions, and drug choices were the most common. Most of TRPs identified by pharmacists were clinically significant. Pharmacists' interventions contributed substantially to the resolving of many of the identified TRPs. Patients suffering from higher number of medical conditions and receiving higher number of medications should be given the priority for clinical pharmacy service in hospitalized internal medicine patients.
本研究旨在确定约旦住院内科患者治疗相关问题（TRP）的流行率和特征，以及确定与每种特定 TRP 相关的疾病和药物。我们还旨在调查医生对临床药师建议的接受程度，并确定药师干预的结果。
约旦一家综合医院的内科病房。
我们采用了系统、前瞻性、床边、全面的临床评估方法，使我们能够有效地识别、沟通和跟踪 TRP。
确定的 TRP 的流行率和性质、TRP 的临床意义、相关疾病和药物以及临床药师干预的临床结果。
共纳入 402 例患者。确定的 TRP 平均数量为 9.35。53%的 TRP 被归类为主要，28%的 TRP 被归类为中度。91%的建议被医生接受。与疗效相关的问题是最常见的 TRP 类别，其次是与安全性相关的问题和与适应症相关的问题。通过临床药师干预，64%的 TRP 得到解决或预防。
我们发现内科住院患者的 TRP 发生率相当高。与剂量方案、未治疗的疾病、患者监测、药物相互作用和药物选择相关的 TRP 最为常见。药师发现的大多数 TRP 具有临床意义。药师的干预对解决许多已确定的 TRP 做出了重大贡献。在住院内科患者中，应优先为患有更多疾病和接受更多药物治疗的患者提供临床药学服务。
