Ellis L M, Wittliff J L, Bryant M S, Hogancamp W E, Sitren H S, Bland K I
Department of Surgery, University of Florida, Gainesville.
Am J Surg. 1989 Jun;157(6):577-80; discussion 581. doi: 10.1016/0002-9610(89)90704-6.
Breast cancer was induced in female Holtzman rats by intragastric administration of 7,12-dimethylbenz[a]antracene (DMBA). At tumor maturity, biopsies of viable tissue were obtained, frozen, and then assayed for estrogen, progesterone, and androgen receptor content. By simple linear regression analysis, progesterone receptor levels significantly correlated with both estrogen and androgen receptor levels, whereas estrogen and androgen receptor levels did not correlate with each other. Multiple regression analyses further substantiated the predictive value of the progesterone receptor for the other two hormone receptors. Knowledge of breast tumor androgen receptor levels may further enhance the value of the estrogen receptor and progesterone receptor in hormonal responsiveness. Further, the progesterone receptor may be the most sensitive of the steroid hormone receptors for selecting patients likely to respond to hormonal therapy.
通过给雌性霍尔茨曼大鼠灌胃7,12-二甲基苯并[a]蒽（DMBA）诱导乳腺癌。在肿瘤成熟时，获取活组织活检样本，冷冻后检测雌激素、孕激素和雄激素受体含量。通过简单线性回归分析，孕激素受体水平与雌激素和雄激素受体水平均显著相关，而雌激素和雄激素受体水平彼此不相关。多元回归分析进一步证实了孕激素受体对其他两种激素受体的预测价值。了解乳腺肿瘤雄激素受体水平可能会进一步提高雌激素受体和孕激素受体在激素反应性方面的价值。此外，孕激素受体可能是用于选择可能对激素治疗有反应的患者的类固醇激素受体中最敏感的。
