Admon Andrew J, Seymour Christopher W, Gershengorn Hayley B, Wunsch Hannah, Cooke Colin R
Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Department of Critical Care, Department of Emergency Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, PA.
Chest. 2014 Dec;146(6):1452-1461. doi: 10.1378/chest.14-0059.
Variation in the use of ICUs for low-risk conditions contributes to health system inefficiency. We sought to examine the relationship between ICU use for patients with pulmonary embolism (PE) and cost, mortality, readmission, and procedure use.
We performed a retrospective cohort study including 61,249 adults with PE discharged from 263 hospitals in three states between 2007 and 2010. We generated hospital-specific ICU admission rate quartiles and used a series of multilevel models to evaluate relationships between admission rates and risk-adjusted in-hospital mortality, readmission, and costs and between ICU admission rates and several critical care procedures.
Hospital quartiles varied in unadjusted ICU admission rates for PE (range, ≤ 15% to > 31%). Among all patients, there was a small trend toward increased use of arterial catheterization (0.6%-1.1%, P < .01) in hospital quartiles with higher levels of ICU admission. However, use of invasive mechanical ventilation (14.4%-7.9%, P < .01), noninvasive ventilation (6.6%-3.0%, P < .01), central venous catheterization (14.6%-11.3%, P < .02), and thrombolytics (11.0%-4.7%, P < .01) in patients in the ICU declined across hospital quartiles. There was no relationship between ICU admission rate and risk-adjusted hospital mortality, costs, or readmission.
Hospitals vary widely in ICU admission rates for acute PE without a detectable impact on mortality, cost, or readmission. Patients admitted to ICUs in higher-using hospitals received many critical care procedures less often, suggesting that these patients may have had weaker indications for ICU admission. Hospitals with greater ICU admission may be appropriate targets for improving efficiency in ICU admissions.
对低风险病情使用重症监护病房(ICU)存在差异,这导致了卫生系统效率低下。我们试图研究肺栓塞(PE)患者使用ICU与成本、死亡率、再入院率及诊疗程序使用之间的关系。
我们进行了一项回顾性队列研究,纳入了2007年至2010年间从三个州的263家医院出院的61249例成年PE患者。我们生成了各医院特定的ICU入院率四分位数,并使用一系列多水平模型来评估入院率与风险调整后的院内死亡率、再入院率及成本之间的关系,以及ICU入院率与几种重症监护诊疗程序之间的关系。
各医院四分位数在未经调整的PE患者ICU入院率方面存在差异(范围为≤15%至>31%)。在所有患者中,ICU入院水平较高的医院四分位数中,动脉导管插入术的使用有小幅增加趋势(0.6% - 1.1%,P <.01)。然而,ICU患者中侵入性机械通气(14.4% - 7.9%,P <.01)、无创通气(6.6% - 3.0%,P <.01)、中心静脉导管插入术(14.6% - 11.3%,P <.02)及溶栓药物(11.0% - 4.7%,P <.01)的使用在各医院四分位数中呈下降趋势。ICU入院率与风险调整后的医院死亡率、成本或再入院率之间没有关系。
医院在急性PE患者的ICU入院率方面差异很大,对死亡率、成本或再入院率没有可检测到的影响。在ICU使用率较高的医院入院的患者接受许多重症监护诊疗程序的频率较低,这表明这些患者可能入住ICU的指征较弱。ICU入院率较高的医院可能是提高ICU入院效率的合适目标。