Kırım Sinan, Keşkek Şakir Özgür, Turhan Ali, Saler Tayyibe
Department of Internal Medicine, Numune Education and Research Hospital, Adana, Turkey.
Med Princ Pract. 2014;23(5):421-5. doi: 10.1159/000363603. Epub 2014 Jul 3.
To investigate the frequency of metabolic syndrome and its components in subjects with β-thalassaemia minor.
A total of 194 subjects, i.e. 92 subjects with β-thalassaemia minor (study group) and 102 subjects without β-thalassaemia minor (control group), were enrolled into this case-control study. Haemoglobin electrophoresis was performed on all patients. The waist circumference and systolic and diastolic blood pressure of the subjects were recorded. Fasting blood glucose and serum lipid levels were measured.
Both groups were similar in terms of age and sex (p > 0.05 for each). The percentages of haemoglobin A2 (4.3 ± 0.4 vs. 2.0 ± 0.3) and haemoglobin F (3.38 ± 1.4 vs. 0.26 ± 0.4) and the mean corpuscular volumes (64 ± 4.7 vs. 81.5 ± 9.3) of the groups were statistically different (p < 0.001 for each). The frequency of metabolic syndrome and its components was similar in both groups (p > 0.05 for each). According to correlation analyses, the percentage of haemoglobin A2 correlated with fasting insulin, fasting glucose, systolic blood pressure, high-density lipoprotein, and low-density lipoprotein levels (p < 0.05).
No association was found between β-thalassaemia minor and metabolic syndrome despite insulin resistance, which was shown in subjects with β-thalassaemia minor.
研究轻型β地中海贫血患者代谢综合征及其组分的发生频率。
本病例对照研究共纳入194名对象，即92名轻型β地中海贫血患者（研究组）和102名非轻型β地中海贫血患者（对照组）。对所有患者进行血红蛋白电泳。记录对象的腰围、收缩压和舒张压。测量空腹血糖和血脂水平。
两组在年龄和性别方面相似（各项p>0.05）。两组的血红蛋白A2百分比（4.3±0.4对2.0±0.3）、血红蛋白F百分比（3.38±1.4对0.26±0.4）及平均红细胞体积（64±4.7对81.5±9.3）差异有统计学意义（各项p<0.001）。两组代谢综合征及其组分的发生频率相似（各项p>0.05）。根据相关性分析，血红蛋白A2百分比与空腹胰岛素、空腹血糖、收缩压、高密度脂蛋白及低密度脂蛋白水平相关（p<0.05）。
尽管轻型β地中海贫血患者存在胰岛素抵抗，但未发现轻型β地中海贫血与代谢综合征之间存在关联。
