Del Prete Stefania, Arpón Javier, Sakai Kaori, Andrey Philippe, Gaudin Valérie
INRA, UMR1318-AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), INRA-Centre de Versailles-Grignon, Versailles, France.
Cytogenet Genome Res. 2014;143(1-3):28-50. doi: 10.1159/000363724. Epub 2014 Jun 28.
The interphase cell nucleus is extraordinarily complex, ordered, and dynamic. In the last decade, remarkable progress has been made in deciphering the functional organisation of the cell nucleus, and intricate relationships between genome functions (transcription, DNA repair, or replication) and various nuclear compartments have been revealed. In this review, we describe the architecture of the Arabidopsis thaliana interphase cell nucleus and discuss the dynamic nature of its organisation. We underline the need for further developments in quantitative and modelling approaches to nuclear organization.
间期细胞核极其复杂、有序且具有动态性。在过去十年中，在解读细胞核的功能组织方面取得了显著进展，并且揭示了基因组功能（转录、DNA修复或复制）与各种核区室之间的复杂关系。在本综述中，我们描述了拟南芥间期细胞核的结构，并讨论了其组织的动态性质。我们强调在核组织的定量和建模方法方面需要进一步发展。
