Chen Bertha, Dave Bhumy
Department of Ob/Gyn, Stanford University Medical Center, 300 Pasteur Dr. HH-333, Stanford, CA, 94305, USA,
Curr Urol Rep. 2014 Aug;15(8):425. doi: 10.1007/s11934-014-0425-2.
With advances in material engineering there is now a wide array of new materials for augmentation of tissue repairs in Female Pelvic Medicine and Reconstructive Surgery (FPMRS). However, clinical outcomes are discrepant and long term complications debilitating. In this manuscript, we describe the molecular and cellular host environments and biomechanical considerations that affect optimal integration of implant materials. There is growing interest in biodegradable scaffolds with cellular implants. It is thought that the cellular component could regenerate host tissue while the scaffold provides temporary mechanical properties. Current findings are promising, but detailed in vivo and long term testing is needed before clinical applications.
随着材料工程的进步，现在有各种各样的新材料可用于女性盆腔医学与重建手术（FPMRS）中的组织修复增强。然而，临床结果存在差异，长期并发症令人衰弱。在本手稿中，我们描述了影响植入材料最佳整合的分子和细胞宿主环境以及生物力学因素。对带有细胞植入物的可生物降解支架的兴趣与日俱增。人们认为细胞成分可以再生宿主组织，而支架提供临时的机械性能。目前的研究结果很有前景，但在临床应用之前还需要进行详细的体内和长期测试。
