经瞬时弹性成像证实的血液透析患者非酒精性脂肪性肝病：它是不良心血管事件的新危险因素吗？
Non-alcoholic fatty liver disease proven by transient elastography in hemodialysis patients: is it a new risk factor for adverse cardiovascular events?
作者信息
Mikolasevic Ivana, Orlic Lidija, Milic Sandra, Zaputovic Luka, Lukenda Vesna, Racki Sanjin
机构信息
Division of Internal Medicine, Department of Nephrology and Dialysis, University Hospital Center Rijeka, Rijeka, Croatia.
出版信息
Blood Purif. 2014;37(4):259-65. doi: 10.1159/000360270. Epub 2014 Jul 3.
BACKGROUND/AIMS: Cardiovascular diseases (CVD) are the leading cause of mortality in hemodialysis (HD) patients. Recently, non-alcoholic fatty liver disease (NAFLD) has been recognized as a new risk factor for adverse CVD events in the general population. Our aim was to analyze the incidence of NAFLD in HD patients by using transient elastography and to analyze whether the presence of NAFLD is associated with a higher CVD risk in HD patients.
METHODS
The subjects were 72 HD patients and 50 sex- and age-matched controls.
RESULTS
NAFLD was found in 52.8% of HD patients. HD patients with NAFLD showed more carotid atherosclerosis and more adverse CVD events than HD patients without NAFLD and control subjects.
CONCLUSION
We showed for the first time that HD patients have a high prevalence of NAFLD. HD patients with NAFLD show an advanced carotid atherosclerosis. Detection of NAFLD by transient elastography should alert to the existence of an increased cardiovascular risk in HD patients.
背景/目的：心血管疾病（CVD）是血液透析（HD）患者死亡的主要原因。最近，非酒精性脂肪性肝病（NAFLD）已被认为是普通人群中不良CVD事件的一个新的危险因素。我们的目的是通过瞬时弹性成像分析HD患者中NAFLD的发生率，并分析NAFLD的存在是否与HD患者较高的CVD风险相关。
方法
研究对象为72例HD患者和50例性别及年龄匹配的对照者。
结果
52.8%的HD患者存在NAFLD。与无NAFLD的HD患者及对照者相比，患有NAFLD的HD患者表现出更多的颈动脉粥样硬化和更多的不良CVD事件。
结论
我们首次表明HD患者中NAFLD的患病率很高。患有NAFLD的HD患者表现出晚期颈动脉粥样硬化。通过瞬时弹性成像检测到NAFLD应提醒注意HD患者心血管风险增加的存在。
Zotero 插件