• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

炎症的消退：靶向与脂质和肽相互作用的G蛋白偶联受体

Resolution of inflammation: targeting GPCRs that interact with lipids and peptides.

作者信息

Cash Jenna L, Norling Lucy V, Perretti Mauro

机构信息

The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.

The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.

出版信息

Drug Discov Today. 2014 Aug;19(8):1186-92. doi: 10.1016/j.drudis.2014.06.023. Epub 2014 Jun 30.

DOI:10.1016/j.drudis.2014.06.023
PMID:24993159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4154450/
Abstract

There is a growing appreciation of the important role of resolution mediators in the successful termination of the inflammatory response. Here, we discuss the potential importance of the lipid and peptide proresolving mediators, in particular the resolvins and chemerin-derived peptides, which mediate their effects through specific G protein-coupled receptors (GPCRs).

摘要

人们越来越认识到消退介质在炎症反应成功终止中的重要作用。在此，我们讨论脂质和肽类促消退介质的潜在重要性，特别是消退素和趋化素衍生肽，它们通过特定的G蛋白偶联受体（GPCR）介导其作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297c/4154450/1111581d35a1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297c/4154450/c4402be230b8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297c/4154450/1111581d35a1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297c/4154450/c4402be230b8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297c/4154450/1111581d35a1/gr2.jpg

相似文献

1
Resolution of inflammation: targeting GPCRs that interact with lipids and peptides.炎症的消退：靶向与脂质和肽相互作用的G蛋白偶联受体
Drug Discov Today. 2014 Aug;19(8):1186-92. doi: 10.1016/j.drudis.2014.06.023. Epub 2014 Jun 30.
2
G-Protein Coupled Receptors Involved in the Resolution of Inflammation: Ligands and Therapeutic Perspectives.G 蛋白偶联受体在炎症消退中的作用：配体和治疗前景。
Mini Rev Med Chem. 2020;20(20):2090-2103. doi: 10.2174/1389557520666200719014433.
3
Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain.一种膜锚定趋化素受体激动剂的开发，作为一种新型的变应性气道炎症和神经病理性疼痛的调节剂。
J Biol Chem. 2014 May 9;289(19):13385-96. doi: 10.1074/jbc.M113.522680. Epub 2014 Mar 21.
4
Roles of resolvins in the resolution of acute inflammation.消退素在急性炎症消退过程中的作用。
Cell Biol Int. 2015 Jan;39(1):3-22. doi: 10.1002/cbin.10345. Epub 2014 Sep 17.
5
Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction.炎症和促消退介质在内皮功能障碍中的作用。
Basic Clin Pharmacol Toxicol. 2025 May;136(5):e70026. doi: 10.1111/bcpt.70026.
6
Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins.神经退行性疾病中炎症的消退：消退素的作用
Mediators Inflamm. 2020 Mar 25;2020:3267172. doi: 10.1155/2020/3267172. eCollection 2020.
7
The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.G 蛋白偶联受体-瞬时受体电位通道轴：靶向感觉和炎症障碍的分子见解。
Pharmacol Rev. 2015;67(1):36-73. doi: 10.1124/pr.114.009555.
8
Nonpeptide ligands that target peptide-activated GPCRs in inflammation.靶向炎症中肽激活的G蛋白偶联受体的非肽配体。
Curr Med Chem. 2005;12(25):3027-42. doi: 10.2174/092986705774462888.
9
Synthetic chemerin-derived peptides suppress inflammation through ChemR23.合成的促凝素衍生肽通过ChemR23抑制炎症。
J Exp Med. 2008 Apr 14;205(4):767-75. doi: 10.1084/jem.20071601. Epub 2008 Apr 7.
10
Understanding Peptide Binding in Class A G Protein-Coupled Receptors.了解 A 类 G 蛋白偶联受体中的肽结合。
Mol Pharmacol. 2019 Nov;96(5):550-561. doi: 10.1124/mol.119.115915. Epub 2019 Jul 10.

引用本文的文献

1
Discovery and Optimization of Aryl Piperidinone Ureas as Selective Formyl Peptide Receptor 2 Agonists.芳基哌啶酮脲类作为选择性甲酰肽受体2激动剂的发现与优化
ACS Med Chem Lett. 2024 Aug 12;15(9):1500-1505. doi: 10.1021/acsmedchemlett.4c00172. eCollection 2024 Sep 12.
2
Plasma Chemerin Is Induced in Critically Ill Patients with Gram-Positive Infections.血浆趋化素在革兰氏阳性菌感染的重症患者中升高。
Biomedicines. 2023 Jun 21;11(7):1779. doi: 10.3390/biomedicines11071779.
3
Effect of non-surgical periodontal treatment on visfatin and chemerin concentration in the gingival crevicular fluid.

本文引用的文献

1
CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury.CD73+ 调节性 T 细胞有助于通过腺苷介导的急性肺损伤解决。
FASEB J. 2013 Jun;27(6):2207-19. doi: 10.1096/fj.12-225201. Epub 2013 Feb 14.
2
Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses.解析素 D1 和阿司匹林触发的解析素 D1 促进过敏性气道反应的消退。
J Immunol. 2012 Aug 15;189(4):1983-91. doi: 10.4049/jimmunol.1101665. Epub 2012 Jul 16.
3
Resolvin E2 formation and impact in inflammation resolution.
非手术牙周治疗对龈沟液中内脂素和趋化素浓度的影响。
Odontology. 2024 Jan;112(1):200-207. doi: 10.1007/s10266-023-00808-x. Epub 2023 Mar 28.
4
Inflammation-Controlled Anti-Inflammatory Hydrogels.炎症控制型抗炎水凝胶。
Adv Sci (Weinh). 2023 Mar;10(7):e2206412. doi: 10.1002/advs.202206412. Epub 2022 Dec 29.
5
Urinary chemerin as a potential biomarker for inflammatory bowel disease.尿chemerin作为炎症性肠病的潜在生物标志物。
Front Med (Lausanne). 2022 Nov 10;9:1058108. doi: 10.3389/fmed.2022.1058108. eCollection 2022.
6
Chemerin as a Potential Marker of Resolution of Inflammation in COVID-19 Infection.Chemerin作为新冠病毒感染炎症消退的潜在标志物
Biomedicines. 2022 Oct 1;10(10):2462. doi: 10.3390/biomedicines10102462.
7
Role of macrophages during skeletal muscle regeneration and hypertrophy-Implications for immunomodulatory strategies.肌生成和肥大过程中巨噬细胞的作用——对免疫调节策略的启示。
Physiol Rep. 2022 Oct;10(19):e15480. doi: 10.14814/phy2.15480.
8
Targeting Angiogenesis via Resolution of Inflammation.靶向血管生成以缓解炎症。
Cold Spring Harb Perspect Med. 2023 Mar 1;13(3):a041172. doi: 10.1101/cshperspect.a041172.
9
Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts.特殊促消退介质不抑制肿瘤坏死因子-α诱导的滑膜成纤维细胞中炎症介质的合成。
Yonago Acta Med. 2022 Apr 16;65(2):111-125. doi: 10.33160/yam.2022.05.001. eCollection 2022 May.
10
Molecular Pharmacology of Inflammation Resolution in Atherosclerosis.动脉粥样硬化中炎症消退的分子药理学。
Int J Mol Sci. 2022 Apr 27;23(9):4808. doi: 10.3390/ijms23094808.
解析 E2 的形成及其在炎症消退中的作用。
J Immunol. 2012 May 1;188(9):4527-34. doi: 10.4049/jimmunol.1103652. Epub 2012 Mar 26.
4
The effect of galectins on leukocyte trafficking in inflammation: sweet or sour?半乳凝素在炎症中对白细胞迁移的影响：是甜蜜还是酸涩？
Ann N Y Acad Sci. 2012 Apr;1253:181-92. doi: 10.1111/j.1749-6632.2011.06291.x. Epub 2012 Jan 18.
5
Galectin-9 ameliorates herpes simplex virus-induced inflammation through apoptosis.半乳糖凝集素-9 通过细胞凋亡减轻单纯疱疹病毒诱导的炎症反应。
Immunobiology. 2012 Jun;217(6):657-66. doi: 10.1016/j.imbio.2011.11.002. Epub 2011 Nov 18.
6
Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.解析素 D2 是瞬时受体电位亚型 V1/A1、炎性疼痛和小鼠脊髓突触可塑性的有效内源性抑制剂：解析素 D1、D2 和 E1 的不同作用。
J Neurosci. 2011 Dec 14;31(50):18433-8. doi: 10.1523/JNEUROSCI.4192-11.2011.
7
ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia.ChemR23 可抑制急性病毒性肺炎小鼠模型中的肺部炎症并增强抗病毒免疫。
PLoS Pathog. 2011 Nov;7(11):e1002358. doi: 10.1371/journal.ppat.1002358. Epub 2011 Nov 3.
8
Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1.局部侵袭性牙周炎中的吞噬作用受损：Resolvin E1 的挽救作用。
PLoS One. 2011;6(9):e24422. doi: 10.1371/journal.pone.0024422. Epub 2011 Sep 14.
9
Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins.人半胱氨酸蛋白酶对趋化素化学引诱物和抗菌活性的调节作用。
J Immunol. 2011 Aug 1;187(3):1403-10. doi: 10.4049/jimmunol.1002352. Epub 2011 Jun 29.
10
n-3 fatty acids in cardiovascular disease.心血管疾病中的n-3脂肪酸
N Engl J Med. 2011 Jun 23;364(25):2439-50. doi: 10.1056/NEJMra1008153.