Gulhane Faculty of Dental Medicine, University of Health Sciences, Ankara, Turkey.
Department of Basic Sciences, Medical Biochemistry, Acibadem Mehmet Ali Aydinlar University, Ankara, Turkey.
Odontology. 2024 Jan;112(1):200-207. doi: 10.1007/s10266-023-00808-x. Epub 2023 Mar 28.
Visfatin, as a novel adipokine, is considered to play a role in periodontal inflammation. Chemerin is another newly identified adipokine that is possible to have a role in periodontitis firstly reported in our previous study. The aim of the current study is to evaluate the gingival crevicular fluid (GCF) levels of visfatin and chemerin in periodontitis and and compare these adipokine levels with before and after non-surgical periodontal treatment. Twenty-nine patients with Stage III Grade B periodontitis and eighteen healthy subjects included in this cross-sectional cohort study. Clinical periodontal parameters and GCF were obtained from all subjects. Eight weeks after the following non-surgical periodontal treatment including scaling and root planning, samples and clinical periodontal parameters were collected again in the periodontitis group. The levels of adipokines were analyzed with standard enzyme-linked immunosorbent assay. The levels of visfatin and chemerin were statistically significantly higher at periodontitis group as compared to healthy group (P < 0.001). Although, no changes were observed in visfatin levels after periodontal treatment (P > 0.05), chemerin levels were significantly decreased (P < 0.001). Also, no differences were observed as compared to the healthy group (P > 0.05). Visfatin and chemerin may play a role in the periodontal disease process. In addition, it can be considered that the decreased chemerin levels after non-surgical periodontal treatment may play an important role for developing host modulation strategies.
内脏脂肪素作为一种新型脂肪因子，被认为在牙周炎症中发挥作用。趋化素是另一种新发现的脂肪因子，它可能在牙周炎中发挥作用，这在我们之前的研究中首次报道。本研究旨在评估牙周炎患者龈沟液（GCF）中内脏脂肪素和趋化素的水平，并将这些脂肪因子水平与牙周非手术治疗前后进行比较。本横断面队列研究纳入 29 例牙周炎Ⅲ期 B 级患者和 18 例健康对照者。所有受试者均获得临床牙周参数和 GCF。牙周炎组在接受包括洁治和根面平整在内的非手术牙周治疗 8 周后，再次采集样本和临床牙周参数。采用标准酶联免疫吸附试验分析脂肪因子水平。与健康组相比，牙周炎组的内脏脂肪素和趋化素水平明显升高（P<0.001）。尽管牙周治疗后内脏脂肪素水平无变化（P>0.05），但趋化素水平显著降低（P<0.001），且与健康组相比差异无统计学意义（P>0.05）。内脏脂肪素和趋化素可能在牙周病的发病机制中发挥作用。此外，非手术牙周治疗后趋化素水平降低可能对开发宿主调节策略具有重要意义。
