Aldaz C M, Trono D, Larcher F, Slaga T J, Conti C J
Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smitville 78957.
Mol Carcinog. 1989;2(1):22-6. doi: 10.1002/mc.2940020104.
Using a direct cytogenetic technique, we identified a nonrandom trisomy of chromosome 6 in 12 of 12 aneuploid mouse skin papillomas and in 10 of 11 squamous cell carcinomas induced by chemical carcinogenesis. The second most common abnormality observed was trisomy of chromosome 7 found in most dysplastic papillomas and in 10 of 11 carcinomas. The two trisomies were the only abnormalities found in all aneuploid papillomas and in several carcinomas. Mutation at codon 61 of the Ha-ras gene, which resides on chromosome 7, was also a common feature of the tumors sampled. Extensive homology exists between mouse chromosome 6 and human chromosome 7, the trisomy of which was recently suggested as a primary cytogenetic event in several human epithelial cancers. We propose a multistep model of tumor progression in which a sequence of specific nonrandom chromosomal abnormalities appear to be required for malignant transformation.
运用直接细胞遗传学技术，我们在12个非整倍体小鼠皮肤乳头瘤中的12个以及化学致癌诱导产生的11个鳞状细胞癌中的10个中，鉴定出6号染色体的非随机三体性。观察到的第二常见异常是7号染色体三体性，在大多数发育异常的乳头瘤以及11个癌中的10个中发现。这两种三体性是在所有非整倍体乳头瘤和一些癌中发现的仅有的异常。位于7号染色体上的Ha-ras基因第61密码子的突变也是所采样肿瘤的一个常见特征。小鼠6号染色体与人类7号染色体之间存在广泛的同源性，最近有人提出人类7号染色体三体性是几种人类上皮癌中的主要细胞遗传学事件。我们提出一个肿瘤进展的多步骤模型，其中一系列特定的非随机染色体异常似乎是恶性转化所必需的。
