Department of Thoracic/Head and Neck Medical Oncology , University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 085, Houston, TX 77030, USA.
Proc Am Thorac Soc. 2012 May;9(2):38-42. doi: 10.1513/pats.201201-004MS.
Lung cancer, of which non-small cell lung cancer (NSCLC) composes the majority, is the leading cause of cancer-related deaths in the United States and worldwide. NSCLCs are tumors with complex biology that we have recently started to understand with the advent of various histological, transcriptomic, genomic, and proteomic technologies. However, the histological and molecular pathogenesis of this malignancy, in particular of adenocarcinomas, is still largely unknown. Earlier studies have highlighted a field cancerization phenomenon in which histologically normal-appearing tissue adjacent to neoplastic and pre-neoplastic lesions display molecular abnormalities, some of which are in common with those in the tumors. This review will summarize advances in understanding the field cancerization phenomenon and the potential relevance of this knowledge to gain important and novel insights into the molecular pathogenesis of NSCLC as well as to subsequent development of biomarkers for early detection of lung cancers and possibly personalized prevention.
肺癌是美国和全球癌症相关死亡的主要原因，其中非小细胞肺癌（NSCLC）占大多数。NSCLCs 是具有复杂生物学特性的肿瘤，随着各种组织学、转录组学、基因组学和蛋白质组学技术的出现，我们最近才开始了解这种肿瘤。然而，这种恶性肿瘤，特别是腺癌的组织学和分子发病机制在很大程度上仍然未知。早期的研究强调了一种场癌变现象，即与肿瘤和癌前病变相邻的组织学上正常的组织显示出分子异常，其中一些与肿瘤中的异常相同。这篇综述将总结对场癌变现象的理解进展，以及这些知识对深入了解 NSCLC 的分子发病机制以及随后开发用于早期发现肺癌和可能进行个体化预防的生物标志物的潜在相关性。
