Wushou Alimujiang, Zhao Ya-Jun, Shao Zhi-Ming
Cancer Research Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, PR China; Department Oral & Maxillofacial Surgery Department, College and Hospital of Stomatology, Xi'an Jiao Tong University, Xi'an 710004, PR China.
Department Oral & Maxillofacial Surgery Department, College and Hospital of Stomatology, Xi'an Jiao Tong University, Xi'an 710004, PR China.
J Craniomaxillofac Surg. 2014 Oct;42(7):1540-4. doi: 10.1016/j.jcms.2014.04.027. Epub 2014 May 2.
Previous published studies fail to present any consensus on a uniform treatment protocol for keratocystic odontogenic tumour (KCOT). Optimal management for KCOT was investigated by comparing the treatment outcome of marsupialization to the enucleation and radical resection. An online electronic databases search was carried out through the PubMed, Embase and Web of Science. The statistical analysis was performed by RevMan version 5.2. Fourteen eligible studies were identified for analysis. Fourteen studies evaluated included 938 patients, of which 853 underwent enucleation alone or plus adjunctive therapy, 110 underwent marsupialization with or without secondary adjunctive therapy, and 86 underwent radical resection alone. The marsupialization was significantly associated with lower recurrence compared to enucleation and resection in KCOT treatment (RR = 0.56, 95% CI 0.4-0.78, P = 0.0006 and RR = 0.32, 95% CI 0.15-0.69, P = 0.004, respectively). The results suggest that the marsupialization reduce the recurrence of KCOT better than enucleation and surgical resection and it may be the optimal approach for KCOT treatment.
以往发表的研究未能就牙源性角化囊性瘤（KCOT）的统一治疗方案达成共识。通过比较袋形术与摘除术和根治性切除术的治疗结果，研究了KCOT的最佳治疗方法。通过PubMed、Embase和Web of Science进行在线电子数据库搜索。使用RevMan 5.2版进行统计分析。确定了14项符合条件的研究进行分析。纳入评估的14项研究包括938例患者，其中853例仅接受摘除术或联合辅助治疗，110例接受袋形术，有或无二次辅助治疗，86例仅接受根治性切除术。在KCOT治疗中，与摘除术和切除术相比，袋形术与较低的复发率显著相关（RR = 0.56，95% CI 0.4 - 0.78，P = 0.0006；RR = 0.32，95% CI 0.15 - 0.69，P = 0.004）。结果表明，袋形术比摘除术和手术切除能更好地降低KCOT的复发率，可能是KCOT治疗的最佳方法。
