Kretzschmar Kai, Watt Fiona M
Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, United Kingdom Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom.
Cold Spring Harb Perspect Med. 2014 Jul 3;4(10):a013631. doi: 10.1101/cshperspect.a013631.
The epidermis is the outermost layer of mammalian skin and comprises a multilayered epithelium, the interfollicular epidermis, with associated hair follicles, sebaceous glands, and eccrine sweat glands. As in other epithelia, adult stem cells within the epidermis maintain tissue homeostasis and contribute to repair of tissue damage. The bulge of hair follicles, where DNA-label-retaining cells reside, was traditionally regarded as the sole epidermal stem cell compartment. However, in recent years multiple stem cell populations have been identified. In this review, we discuss the different stem cell compartments of adult murine and human epidermis, the markers that they express, and the assays that are used to characterize epidermal stem cell properties.
表皮是哺乳动物皮肤的最外层，由多层上皮组织即毛囊间表皮以及相关的毛囊、皮脂腺和汗腺组成。与其他上皮组织一样，表皮内的成体干细胞维持组织稳态并有助于修复组织损伤。毛囊隆突部是DNA标记保留细胞所在的部位，传统上被认为是唯一的表皮干细胞区室。然而，近年来已鉴定出多个干细胞群体。在这篇综述中，我们讨论了成年小鼠和人类表皮的不同干细胞区室、它们所表达的标志物以及用于表征表皮干细胞特性的检测方法。
