Sobkowska Daria, Gornowicz-Porowska Justyna, Seraszek-Jaros Agnieszka, Słomińska Daria, Adamski Zygmunt, Pawlaczyk Mariola
Department and Division of Practical Cosmetology and Prevention of Skin Diseases, Poznan University of Medical Sciences, Poznań, 60-806, Poland.
Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, Poznań, 60-806, Poland.
Clin Cosmet Investig Dermatol. 2022 Jul 14;15:1347-1355. doi: 10.2147/CCID.S365501. eCollection 2022.
The prevalence of type 2 diabetes mellitus (t2DM) has been steadily increasing. Patients with t2DM need to slow down the skin ageing processes and to obtain a rejuvenating effect. Treatments that do not damage the superficial layers of the epidermis could be a promising solution for those patients.
The aim of this study was to evaluate the effects of radiofrequency therapy on the biophysical parameters and angiogenesis of facial skin, using CD34 as a biomarker in older diabetic women treated with metformin.
A total of 45 subjects with phototype 2 or 3 (Fitzpatrick scale) were investigated (25 t2DM - study group, 20 - healthy controls). A series of 6 treatments (once a week) with a Radio Frequency Skin Rejuvenation System device was used on facial skin. Measurements of skin hydration, transepidermal water loss (TEWL), melanin and erythema index, temperature, and pH, at baseline and after radiofrequency therapy were performed with the Courage + Khazaka MPA-9 device. Immunohistochemistry on paraffin-embedded sections was used to evaluate the intensity of CD34 expression.
Radiofrequency treatment significantly improved facial skin hydration (p < 0.0001). Enhancement of the epidermal barrier observed, by reduced TEWL as a result of a series of treatments with radiofrequency on the facial skin (p < 0.0001), was observed. CD34 was more abundantly expressed after radiofrequency treatment. No side effects were observed.
Treatment with radiofrequency is an effective and non-invasive method of facial skin rejuvenation in older women with t2DM, with a relatively short post-procedure recovery time and low potential for severe adverse effects.
2型糖尿病（T2DM）的患病率一直在稳步上升。T2DM患者需要减缓皮肤衰老过程并获得年轻化效果。对于这些患者而言，不损伤表皮浅层的治疗方法可能是一个有前景的解决方案。
本研究的目的是，以CD34作为生物标志物，评估射频治疗对老年糖尿病女性面部皮肤生物物理参数和血管生成的影响，这些女性患者正在接受二甲双胍治疗。
共调查了45名光型为2或3（ Fitzpatrick量表）的受试者（25名T2DM患者——研究组，20名健康对照者）。使用射频皮肤年轻化系统设备对面部皮肤进行了一系列6次治疗（每周一次）。在基线和射频治疗后，使用Courage + Khazaka MPA - 9设备测量皮肤水合作用、经表皮水分流失（TEWL）、黑色素和红斑指数、温度及pH值。对石蜡包埋切片进行免疫组织化学分析，以评估CD34表达强度。
射频治疗显著改善了面部皮肤水合作用（p < 0.0001）。观察到由于对面部皮肤进行一系列射频治疗，TEWL降低，从而使表皮屏障增强（p < 0.0001）。射频治疗后CD34表达更为丰富。未观察到副作用。
对于患有T2DM的老年女性，射频治疗是一种有效且非侵入性的面部皮肤年轻化方法，术后恢复时间相对较短，严重不良反应的可能性较低。
