Neogi Tuhina, Chen Clara, Niu Jingbo, Chaisson Christine, Hunter David J, Choi Hyon, Zhang Yuqing
Am J Epidemiol. 2014 Aug 15;180(4):372-7. doi: 10.1093/aje/kwu147. Epub 2014 Jul 3.
Gout attack risk may be affected by weather (e.g., because of volume depletion). We therefore examined the association of temperature and humidity with the risk of recurrent gout attacks by conducting an internet-based case-crossover study in the United States (in 2003-2010) among subjects with a diagnosis of gout who had 1 or more attacks during 1 year of follow-up. We examined the association of temperature and humidity over the prior 48 hours with the risk of gout attacks using a time-stratified approach and conditional logistic regression. Among 632 subjects with gout, there was a significant dose-response relationship between mean temperature in the prior 48 hours and the risk of subsequent gout attack (P = 0.01 for linear trend). Higher temperatures were associated with approximately 40% higher risk of gout attack compared with moderate temperatures. There was a reverse J-shaped relationship between mean relative humidity and the risk of gout attacks (P = 0.03 for quadratic trend). The combination of high temperature and low humidity had the greatest association (odds ratio = 2.04, 95% confidence interval: 1.26, 3.30) compared with moderate temperature and relative humidity. Thus, high ambient temperature and possibly extremes of humidity were associated with an increased risk of gout attack, despite the likelihood that individuals are often in climate-controlled indoor environments.
痛风发作风险可能受天气影响（例如，由于血容量减少）。因此，我们通过在美国（2003 - 2010年）对诊断为痛风且在1年随访期间有1次或更多次发作的受试者进行基于互联网的病例交叉研究，来检验温度和湿度与复发性痛风发作风险之间的关联。我们采用时间分层方法和条件逻辑回归，研究前48小时的温度和湿度与痛风发作风险的关联。在632名痛风患者中，前48小时的平均温度与随后痛风发作风险之间存在显著的剂量反应关系（线性趋势P = 0.01）。与中等温度相比，较高温度与痛风发作风险高约40%相关。平均相对湿度与痛风发作风险之间呈倒J形关系（二次趋势P = 0.03）。与中等温度和相对湿度相比，高温和低湿度的组合关联最大（比值比 = 2.04，95%置信区间：1.26，3.30）。因此，尽管个体通常处于有气候控制的室内环境中，但高环境温度以及可能的极端湿度与痛风发作风险增加相关。
