Division of Rheumatology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
J Korean Med Sci. 2020 May 25;35(20):e133. doi: 10.3346/jkms.2020.35.e133.
We purposed to evaluate the seasonality and associated factors of the incidence of gout attacks in Korea.
We prospectively enrolled patients with gout attacks who were treated at nine rheumatology clinics between January 2015 and July 2018 and followed them for 1-year. Demographic data, clinical and laboratory features, and meteorological data including seasonality were collected.
Two hundred-five patients (men, 94.1%) were enrolled. The proportion of patients with initial gout attacks was 46.8% (n = 96). The median age, body mass index, attack duration, and serum uric acid level at enrollment were 50.0 years, 25.4, 5.0 days, and 7.4 mg/dL, respectively. Gout attacks were most common during spring (43.4%, < 0.001) and in March (23.4%, < 0.001). A similar pattern of seasonality was observed in the group with initial gout attacks. Alcohol was the most common provoking factor (39.0%), particularly during summer (50.0%). The median diurnal temperature change on the day of the attack was highest in the spring (9.8°C), followed by winter (9.3°C), fall (8.6°C), and summer (7.1°C) ( = 0.027). The median change in humidity between the 2 consecutive days (the day before and the day of the attack) was significantly different among the seasons (3.0%, spring; 0.3%, summer; -0.9%, fall; -1.2%, winter; = 0.015). One hundred twenty-five (61%) patients completed 1-year follow-up (51% in the initial attack group). During the follow-up period, 64 gout flares developed (21 in the initial attack group). No significant seasonal variation in the follow-up flares was found.
In this prospective study, the most common season and month of gout attacks in Korea are spring and March, respectively. Alcohol is the most common provoking factor, particularly during summer. Diurnal temperature changes on the day of the attack and humidity changes from the day before the attack to the day of the attack are associated with gout attack in our cohort.
我们旨在评估韩国痛风发作的季节性及其相关因素。
我们前瞻性地招募了 2015 年 1 月至 2018 年 7 月期间在九家风湿病诊所接受治疗的痛风发作患者，并对其进行了为期 1 年的随访。收集了人口统计学数据、临床和实验室特征以及气象数据（包括季节性）。
共纳入 205 例患者（94.1%为男性）。初次痛风发作患者的比例为 46.8%（n=96）。入组时的中位年龄、体重指数、发作持续时间和血清尿酸水平分别为 50.0 岁、25.4、5.0 天和 7.4mg/dL。痛风发作最常见于春季（43.4%，<0.001）和 3 月（23.4%，<0.001）。初次痛风发作患者组也存在类似的季节性模式。酒精是最常见的诱发因素（39.0%），尤其是在夏季（50.0%）。发作当天的日温差中位数在春季最高（9.8°C），其次是冬季（9.3°C）、秋季（8.6°C）和夏季（7.1°C）（=0.027）。连续两天（发作前一天和发作当天）湿度的中位数变化在季节之间有显著差异（春季 3.0%，夏季 0.3%，秋季-0.9%，冬季-1.2%，=0.015）。125 例（61%）患者完成了 1 年随访（初次发作组为 51%）。随访期间，64 例痛风发作（初次发作组 21 例）。在随访期间，未发现痛风发作的季节性变化。
在这项前瞻性研究中，韩国痛风发作最常见的季节和月份分别是春季和 3 月。酒精是最常见的诱发因素，尤其是在夏季。发作当天的日温差变化和从发作前一天到发作当天的湿度变化与本队列的痛风发作有关。
