Dogan Zeynal, Sarikaya Murat, Ergul Bilal, Filik Levent
Ankara Education and Research Hospital, Gastroenterology, Turkey.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Jun;159(2):242-5. doi: 10.5507/bp.2014.036. Epub 2014 Jun 19.
Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. These conditions are attributed to systemic inflammation, leptin or ghrelin changes due to H. pylori infection. Therefore, increasing trends in the management of H. pylori infection are ordered to maintain glycemic control. In this study, we evaluated the effect of H. pylori eradication on insulin resistance in patients with normal blood glucose concentrations.
A total of 370 patients with successful eradication were included in the study. Patients with H. pylori were given triple eradication treatment. All patients with H. pylori infection were tested for fasting glucose, fasting insulin, glicated hemoglobin (HbA1c) at baseline and 6 months after eradication treatment. Also, insulin resistance was calculated using the homeostatic model assessment of insulin resistance (HOMA-IR). Body mass index was also determined as a metabolic syndrome criteria effecting insulin resistance.
There were significant differences in fasting glucose, fasting insulin, HbA1c, and HOMA-IR values between before treatment and after treatment(P <0.04, <0.01, <0.01, <0.01). The favorable effect of eradication was more significant in patients with BMI≥25 mg/m(2)(P<0.05).
Eradication treatment has beneficial effects on insulin resistance in patients with normal glucose concentrations.
据报道，幽门螺杆菌（H. pylori）感染与多种胃肠道外疾病有关，如胰岛素抵抗、糖尿病和代谢综合征。这些疾病归因于幽门螺杆菌感染引起的全身炎症、瘦素或胃饥饿素变化。因此，为维持血糖控制，幽门螺杆菌感染的治疗趋势有所增加。在本研究中，我们评估了幽门螺杆菌根除对血糖浓度正常患者胰岛素抵抗的影响。
本研究共纳入370例根除成功的患者。幽门螺杆菌感染患者接受三联根除治疗。所有幽门螺杆菌感染患者在基线及根除治疗后6个月检测空腹血糖、空腹胰岛素、糖化血红蛋白（HbA1c）。此外，使用胰岛素抵抗稳态模型评估（HOMA-IR）计算胰岛素抵抗。体重指数也被确定为影响胰岛素抵抗的代谢综合征标准。
治疗前与治疗后空腹血糖、空腹胰岛素、HbA1c和HOMA-IR值存在显著差异（P<0.04、<0.01、<0.01、<0.01）。根除的有益效果在体重指数≥25 mg/m²的患者中更为显著（P<0.05）。
根除治疗对血糖浓度正常的患者的胰岛素抵抗有有益影响。
