Breustedt W, Rabe H, Volk D, Porstmann P
Dermatol Monatsschr. 1989;175(4):226-31.
28 HIV-infected persons (19 stadium II, 5 stadium III, 4 stadium IV) were investigated for CD4+ lymphocytes, HIV p24 core antigen and urinary neopterin. Monitoring the course of infection repeated estimations were done. Urinary neopterin was found elevated in 26 out of 28 infected people (p less than 0.001). There is an increase in urinary neopterin levels associated with clinical progression in the course of HIV-infection. An inverse correlation to CD4+ lymphocyte count exists. High levels of neopterin early indicate a clinical progression to disease, as well as a decrease of CD4+ lymphocytes below 0.4 or 0.2 Gpt/l, respectively, and a reappearance of HIV p24 core antigen. The course of 5 cases is presented. In HIV-infection urinary neopterin is a suitable marker of activity and progression.
对28例HIV感染者（19例处于Ⅱ期，5例处于Ⅲ期，4例处于Ⅳ期）进行了CD4 +淋巴细胞、HIV p24核心抗原和尿新蝶呤检测。对感染过程进行了反复评估。28例感染者中有26例尿新蝶呤升高（p<0.001）。在HIV感染过程中，尿新蝶呤水平升高与临床进展相关。与CD4 +淋巴细胞计数呈负相关。新蝶呤水平高早期表明疾病临床进展，以及CD4 +淋巴细胞分别降至0.4或0.2 Gpt/l以下，同时HIV p24核心抗原再次出现。展示了5例患者的病程。在HIV感染中，尿新蝶呤是活动和进展的合适标志物。
