Araz Omer, Demirci Elif, Ucar Elif Yilmazel, Calik Muhammet, Karaman Adem, Durur-Subasi Irmak, Orsal Ebru, Subasi Mahmut, Daloglu Ferah, Akgun Metin
Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Turkey.
Respirology. 2014 Oct;19(7):1034-9. doi: 10.1111/resp.12345. Epub 2014 Jul 3.
Most lung cancer (LC) patients have metastatic disease at time of diagnosis, which influence the treatment regimen and is the most important prognostic factor. The main purpose of our study was to evaluate the relationship between cell proliferation (Ki-67 label index), p53, transforming growth factor-β (TGF-β) and lysyl oxidase (LOX), and the metastatic stages of different lung cancers. The secondary aim was to correlate these parameters with the standardized uptake value (SUVmax) of the primary lesion during positron emission tomography-computed tomography (PET-CT).
Eighty-five treatment-naive patients with LC were enrolled. All patients were examined with PET-CT. Ki-67, p53, TGF-β and LOX were evaluated histopathologically.
Small cell lung cancer (SCLC) showed the most intense staining in all parameters. A well-differentiated adenocarcinoma (AC) demonstrated a more diffuse and intense staining than squamous cell carcinoma (SCC). There was no statistically significant relationship between the four parameters and metastases of SCLC and SCC. However, a significant relationship between TGF-β, LOX and metastatic AC was demonstrated with regards to diffusivity and intensity. p53 and Ki-67 did not show a significant relationship. No correlation between SCLC and SCC and SUVmax was found. However, in AC, the diffusivity and intensity of the LOX and p53 staining showed a statistically significant relationship to the SUVmax.
LOX and TGF-β may play roles in metastatic AC. LOX and TGF-β may become markers of metastatic disease and inhibition could be explored for treatment.
大多数肺癌（LC）患者在确诊时已发生转移，这会影响治疗方案，并且是最重要的预后因素。我们研究的主要目的是评估细胞增殖（Ki-67标记指数）、p53、转化生长因子-β（TGF-β）和赖氨酰氧化酶（LOX）与不同肺癌转移阶段之间的关系。次要目的是将这些参数与正电子发射断层扫描-计算机断层扫描（PET-CT）期间原发灶的标准化摄取值（SUVmax）相关联。
纳入85例未经治疗的LC患者。所有患者均接受PET-CT检查。对Ki-67、p53、TGF-β和LOX进行组织病理学评估。
小细胞肺癌（SCLC）在所有参数中染色最为强烈。高分化腺癌（AC）的染色比鳞状细胞癌（SCC）更弥漫且强烈。这四个参数与SCLC和SCC的转移之间无统计学显著关系。然而，就扩散性和强度而言，TGF-β、LOX与转移性AC之间存在显著关系。p53和Ki-67未显示出显著关系。未发现SCLC和SCC与SUVmax之间存在相关性。然而，在AC中，LOX和p53染色的扩散性和强度与SUVmax显示出统计学显著关系。
LOX和TGF-β可能在转移性AC中起作用。LOX和TGF-β可能成为转移性疾病的标志物，可探索对其进行抑制以用于治疗。
