Karaman Adem, Durur-Subasi Irmak, Alper Fatih, Araz Omer, Subasi Mahmut, Demirci Elif, Albayrak Mevlut, Polat Gökhan, Akgun Metin, Karabulut Nevzat
Department of Radiology, Ataturk University, Medical Faculty, Erzurum, Turkey.
Department of Pulmonary Diseases, Ataturk University, Medical Faculty, Erzurum, Turkey.
Radiol Oncol. 2015 Aug 21;49(3):250-5. doi: 10.1515/raon-2015-0032. eCollection 2015 Sep.
The primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADCmin) and Ki-67, an index for cellular proliferation, in non-small cell lung cancers. Also, we aimed to assess whether ADCmin values differ between tumour subtypes and tissue sampling method.
The patients who had diffusion weighted magnetic resonance imaging (DW-MRI) were enrolled retrospectively. The correlation between ADCmin and the Ki-67 index was evaluated.
Ninety three patients, with a mean age 65 ± 11 years, with histopathologically proven adenocarcinoma and squamous cell carcinoma of the lungs and had technically successful DW-MRI were included in the study. The numbers of tumour subtypes were 47 for adenocarcinoma and 46 for squamous cell carcinoma. There was a good negative correlation between ADCmin values and the Ki-67 proliferation index (r = -0.837, p < 0.001). The mean ADCmin value was higher and the mean Ki-67 index was lower in adenocarcinomas compared to squamous cell carcinoma (p < 0.0001). There was no statistical difference between tissue sampling methods.
Because ADCmin shows a good but negative correlation with Ki-67 index, it provides an opportunity to evaluate tumours and their aggressiveness and may be helpful in the differentiation of subtypes non-invasively.
本研究的主要目的是评估非小细胞肺癌中最小表观扩散系数（ADCmin）与细胞增殖指数Ki-67之间的关联。此外，我们旨在评估肿瘤亚型和组织采样方法之间的ADCmin值是否存在差异。
回顾性纳入接受扩散加权磁共振成像（DW-MRI）检查的患者。评估ADCmin与Ki-67指数之间的相关性。
本研究纳入了93例患者，平均年龄65±11岁，经组织病理学证实为肺腺癌和肺鳞状细胞癌，且DW-MRI技术成功。肿瘤亚型中腺癌47例，鳞状细胞癌46例。ADCmin值与Ki-67增殖指数之间存在良好的负相关（r = -0.837，p < 0.001）。与鳞状细胞癌相比，腺癌的平均ADCmin值更高，平均Ki-67指数更低（p < 0.0001）。组织采样方法之间无统计学差异。
由于ADCmin与Ki-67指数呈良好的负相关，它为评估肿瘤及其侵袭性提供了机会，可能有助于无创性地鉴别肿瘤亚型。
