Mahmoudian Saeid, Lenarz Minoo, Esser Karl-Heinz, Salamat Behrouz, Alaeddini Farshid, Dengler Reinhard, Farhadi Mohammad, Lenarz Thomas
Department of Otorhinolaryngology - Medical University of Hannover (MHH), Hannover, Germany.
Int Tinnitus J. 2013;18(1):63-74. doi: 10.5935/0946-5448.20130009.
Residual inhibition (RI) is the temporary inhibition of tinnitus by use of masking stimuli when the device is turned off.
The main aim of this study was to evaluate the effects of RI induced by auditory electrical stimulation (AES) in the primary auditory pathways using early auditory-evoked potentials (AEPs) in subjective idiopathic tinnitus (SIT) subjects.
A randomized placebo-controlled study was conducted on forty-four tinnitus subjects. All enrolled subjects based on the responses to AES, were divided into two groups of RI and Non-RI (NRI). The results of the electrocochleography (ECochG), auditory brain stem response (ABR) and brain stem transmission time (BTT) were determined and compared pre- and post-AES in the studied groups.
The mean differences in the compound action potential (CAP) amplitudes and III/V and I/V amplitude ratios were significantly different between the RI, NRI and PES controls. BTT was significantly decreased associated with RI.
The observed changes in AEP associated with RI suggested some peripheral and central auditory alterations. Synchronized discharges of the auditory nerve fibers and inhibition of the abnormal activity of the cochlear nerve by AES may play important roles associated with RI. Further comprehensive studies are required to determine the mechanisms of RI more precisely.
残余抑制（RI）是指在设备关闭时，通过使用掩蔽刺激来暂时抑制耳鸣。
本研究的主要目的是利用早期听觉诱发电位（AEP）评估主观特发性耳鸣（SIT）患者中，听觉电刺激（AES）在初级听觉通路中诱导的残余抑制的效果。
对44名耳鸣患者进行了一项随机安慰剂对照研究。根据对AES的反应，将所有入组患者分为残余抑制组（RI）和非残余抑制组（NRI）。在研究组中，分别在AES前后测定并比较了耳蜗电图（ECochG）、听性脑干反应（ABR）和脑干传导时间（BTT）的结果。
RI组、NRI组和假电刺激（PES）对照组之间，复合动作电位（CAP）振幅以及III/V和I/V振幅比的平均差异具有显著性。BTT与RI相关且显著降低。
观察到的与RI相关的AEP变化提示了一些外周和中枢听觉改变。听觉神经纤维的同步放电以及AES对耳蜗神经异常活动的抑制可能在RI中起重要作用。需要进一步进行全面研究以更精确地确定RI的机制。
