Austin Mark W, Ploughman Michelle, Glynn Lindsay, Corbett Dale
Recovery and Performance Laboratory, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Recovery and Performance Laboratory, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Neurosci Res. 2014 Oct;87:8-15. doi: 10.1016/j.neures.2014.06.007. Epub 2014 Jul 2.
Aerobic exercise (AE) enhances neuroplasticity and improves functional outcome in animal models of stroke, however the optimal parameters (days post-stroke, intensity, mode, and duration) to influence brain repair processes are not known. We searched PubMed, CINAHL, PsychInfo, the Cochrane Library, and the Central Register of Controlled Clinical Trials, using predefined criteria, including all years up to July 2013 (English language only). Clinical studies were included if participants had experienced an ischemic or hemorrhagic stroke. We included animal studies that utilized any method of global or focal ischemic stroke or intracerebral hemorrhage. Any intervention utilizing AE-based activity with the intention of improving cardiorespiratory fitness was included. Of the 4250 titles returned, 47 studies (all in animal models) met criteria and measured the effects of exercise on brain repair parameters (lesion volume, oxidative damage, inflammation and cell death, neurogenesis, angiogenesis and markers of stress). Our synthesized findings show that early-initiated (24-48h post-stroke) moderate forced exercise (10m/min, 5-7 days per week for about 30min) reduced lesion volume and protected perilesional tissue against oxidative damage and inflammation at least for the short term (4 weeks). The applicability and translation of experimental exercise paradigms to clinical trials are discussed.
有氧运动（AE）可增强神经可塑性，并改善中风动物模型的功能结局，然而，影响脑修复过程的最佳参数（中风后天数、强度、模式和持续时间）尚不清楚。我们使用预定义标准，检索了PubMed、CINAHL、PsychInfo、Cochrane图书馆和对照临床试验中央注册库，检索时间范围包括截至2013年7月的所有年份（仅英文文献）。如果参与者经历过缺血性或出血性中风，则纳入临床研究。我们纳入了采用任何全脑或局灶性缺血性中风或脑出血方法的动物研究。任何旨在提高心肺适应性的基于有氧运动的干预措施均被纳入。在返回的4250篇文献标题中，47项研究（均为动物模型）符合标准，并测量了运动对脑修复参数（损伤体积、氧化损伤、炎症和细胞死亡、神经发生、血管生成和应激标志物）的影响。我们的综合研究结果表明，早期开始的（中风后24 - 48小时）中度强迫运动（10米/分钟，每周5 - 7天，约30分钟）至少在短期内（4周）可减少损伤体积，并保护损伤周围组织免受氧化损伤和炎症。本文还讨论了实验性运动模式在临床试验中的适用性和转化情况。
