Ma Jiexian, Hua Jinsheng, Sha Yinghao, Xie Yanhui
Department of Hematology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Tumour Biol. 2014 Sep;35(9):8439-43. doi: 10.1007/s13277-014-1873-5. Epub 2014 Jul 6.
Whether TLX3 is a predictor of prognosis of pediatric T cell acute lymphocytic leukemia (T-ALL) is controversial, with some studies concluding that it is and others concluding the opposite. Therefore, a systematic review was performed to explore the relationship of TLX3 expression with the prognosis of pediatric T-ALL. The PubMed database, The Cochrane Library, conference proceedings, EMBASE databases, and references of published trials and review articles were searched. Two reviewers independently assessed the quality of the trials and extracted data. Hazard ratios (HRs) for disease-free survival (DFS) and odds ratios (OR) for 5-year DFS were pooled using the STATA package. Ultimately, six trials involving 515 patients with pediatric T-ALL were analyzed. The pooled HR (1.07 [0.32, 3.56], p = 0.91) for DFS and OR (1.30 [0.52, 3.27], p = 0.57) for 5-year DFS showed that the TLX3-positive group showed no statistically significant difference with the TLX3-negative group. Our results suggested that TLX3 expression is not an indicator for the prognosis of pediatric T-ALL.
TLX3是否为小儿T细胞急性淋巴细胞白血病（T-ALL）预后的预测指标存在争议，一些研究得出肯定结论，而另一些则得出相反结论。因此，进行了一项系统评价以探讨TLX3表达与小儿T-ALL预后的关系。检索了PubMed数据库、Cochrane图书馆、会议论文集、EMBASE数据库以及已发表试验和综述文章的参考文献。两名评价者独立评估试验质量并提取数据。使用STATA软件包汇总无病生存（DFS）的风险比（HR）和5年DFS的比值比（OR）。最终，分析了6项涉及515例小儿T-ALL患者的试验。DFS的汇总HR（1.07 [0.32, 3.56]，p = 0.91）和5年DFS的OR（1.30 [0.52, 3.27]，p = 0.57）表明，TLX3阳性组与TLX3阴性组无统计学显著差异。我们的结果提示，TLX3表达不是小儿T-ALL预后的指标。
