Wang Mozhi, Zhang Changwang, Song Yongxi, Wang Zhenning, Wang Yaojia, Luo Fang, Xu Yujie, Zhao Yi, Wu Zhonghua, Xu Yingying
Department of Breast Surgery.
Department of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.
Onco Targets Ther. 2017 Mar 14;10:1561-1573. doi: 10.2147/OTT.S126424. eCollection 2017.
Breast cancer (BC) is the most common malignant tumor among women, with high morbidity and mortality. Its onset, development, metastasis, and prognosis vary among individuals due to the interactions between tumors and host immunity. Many diverse mechanisms have been associated with BC, with immune evasion being the most widely studied to date. Tumor cells can escape from the body's immune response, which targets abnormal components and foreign bodies, using different approaches including modification of surface antigens and modulation of the surrounding environment. In this review, we summarize the mechanisms and factors that impact the immunoediting process and analyze their functions in detail.
乳腺癌（BC）是女性中最常见的恶性肿瘤，发病率和死亡率都很高。由于肿瘤与宿主免疫之间的相互作用，其发病、发展、转移和预后存在个体差异。许多不同的机制都与乳腺癌有关，其中免疫逃逸是迄今为止研究最广泛的。肿瘤细胞可以通过不同的方式逃避机体针对异常成分和异物的免疫反应，包括修饰表面抗原和调节周围环境。在这篇综述中，我们总结了影响免疫编辑过程的机制和因素，并详细分析了它们的功能。
