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经口内镜下肌切开术治疗贲门失弛缓症后的胸部CT

Thoracic CT after peroral endoscopic myotomy for the treatment of achalasia.

作者信息

Cai Ming-Yan, Zhou Ping-Hong, Yao Li-Qing, Zhu Bo-Qun, Liang Liang, Li Quan-Lin

机构信息

Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.

出版信息

Gastrointest Endosc. 2014 Dec;80(6):1046-55. doi: 10.1016/j.gie.2014.05.004. Epub 2014 Jul 3.

DOI:10.1016/j.gie.2014.05.004
PMID:24998467
Abstract

BACKGROUND

Peroral endoscopic myotomy (POEM) is a promising new endoscopic method for the treatment of achalasia.

OBJECTIVE

The aim of this study was to analyze the value of routine postoperative CT of the chest to detect POEM-associated adverse events.

DESIGN

Single-center, retrospective study.

SETTING

Tertiary care center.

PATIENTS AND INTERVENTIONS

Between August 2010 and July 2012, 428 patients underwent POEM. Three hundred postprocedure CT POEM patients were retrospectively analyzed and findings correlated with clinical outcome and management.

MAIN OUTCOME MEASUREMENTS

The frequency of postoperative pathological CT scan findings after POEM and the rate of interventions required for adverse event management.

RESULTS

The main CT findings could be divided into frequent and reversible sequelae of POEM, pneumomediastinum (48%), pneumoperitoneum (37%), and subcutaneous emphysema (28%), and into potential adverse events such as pneumothorax (17%), pleural effusion (66%), pneumonitis (52%), and focal atelectasis (21%). Only 17 of 50 patients with pneumothorax (5.6% of all patients) and 2 of 200 patients with pleural effusion (0.7% of all patients) required interventional treatment based on clinical symptoms. In 1 patient, a hematoma was observed on a CT scan before any clinical manifestation occurred. Increasing age and the use of air instead of CO2 were associated with an increased rate of pneumothorax (P = .031; 95% confidence interval, 1.002-1.049 and P < .001; 95% confidence interval, 0.012-0.157, respectively).

LIMITATIONS

Single-center, retrospective study.

CONCLUSIONS

Routine chest CT scan for achalasia patients undergoing POEM is probably not warranted because of the high rate of minor and clinically irrelevant findings. The use of CO2 is obligatory to reduce related adverse events.

摘要

背景

经口内镜下肌切开术(POEM)是一种治疗贲门失弛缓症很有前景的新型内镜治疗方法。

目的

本研究旨在分析胸部术后常规CT对检测POEM相关不良事件的价值。

设计

单中心回顾性研究。

地点

三级医疗中心。

患者与干预措施

2010年8月至2012年7月期间,428例患者接受了POEM治疗。对300例接受术后CT检查的POEM患者进行回顾性分析,并将检查结果与临床结局及处理方式相关联。

主要观察指标

POEM术后病理CT扫描结果的发生率以及不良事件处理所需的干预率。

结果

主要CT表现可分为POEM常见且可逆的后遗症,即纵隔气肿(48%)、气腹(37%)和皮下气肿(28%),以及潜在不良事件,如气胸(17%)、胸腔积液(66%)、肺炎(52%)和局灶性肺不张(21%)。50例气胸患者中仅17例(占所有患者的5.6%)和200例胸腔积液患者中仅2例(占所有患者的0.7%)根据临床症状需要进行介入治疗。1例患者在未出现任何临床表现之前,CT扫描发现了血肿。年龄增加以及使用空气而非二氧化碳与气胸发生率增加相关(P = 0.031;95%置信区间为1.002 - 1.049;P < 0.001;95%置信区间为0.012 - 0.157)。

局限性

单中心回顾性研究。

结论

由于轻微且与临床无关的发现发生率较高,对接受POEM治疗的贲门失弛缓症患者进行常规胸部CT扫描可能没有必要。必须使用二氧化碳以减少相关不良事件。

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