Wan Guoxing, Li Feng, Li Wenqin, Sun Jianping, Cao Yuwen
Department of Pathology, Shihezi University School of Medicine/Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi 832002, China.
Department of Pathology, Shihezi University School of Medicine/Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi 832002, China. E-mail:
Zhonghua Bing Li Xue Za Zhi. 2014 Mar;43(3):158-62.
To evaluate the published data on association between present/null polymorphism of glutathione S-transferase M1 (GSTM1) and breast cancer risk in Chinese population in order to abttain a more precise and comprehensive estimation of the relationship.
A meta-analysis was performed to investigate the association between GSTM1 polymorphism and susceptibility to breast cancer in Chinese population by searching Pubmed, Embase, Cochrane library, CNKI, VIP, Wanfang and CBD database. The data were screened according to the inclusion and exclusion criteria, and extracted, and the quality of included studies was evaluated. The pooled odds ratios (OR) with 95% confidence intervals (95%CI) were calculated using RevMan 5.2 and Stata 12.0 software. Publication bias and sensitivity analysis were also assessed.
A total of 15 case-control studies involving 5,176 cases and 5 890 controls were included in the meta-analysis. The results showed that individuals with GSTM1 null genotype harbored a significantly increased risk of breast cancer compared to that with GSTM1 non-null genotype in Chinese population (OR=1.34, 95%CI=1.12-1.60, P=0.002). The subgroup analysis by region revealed that the individuals with GSTM1 null genotype were significantly associated with an increased risk of breast cancer in southern and northern China populations (southern: OR=1.14, 95%CI=1.01-1.28, P=0.03; northern: OR=2.65, 95%CI=2.04-3.34, P<0.01).
The current meta-analysis demonstrates that the GSTM1 polymorphism is significantly associated with susceptibility to breast cancer in Chinese population, and the GSTM1-deficit may increase the risk of breast cancer.
评估已发表的关于谷胱甘肽S-转移酶M1（GSTM1）的现有/缺失多态性与中国人群乳腺癌风险之间关联的数据，以便更精确和全面地估计两者关系。
通过检索PubMed、Embase、Cochrane图书馆、中国知网、维普、万方和中国生物医学文献数据库，进行荟萃分析以研究中国人群中GSTM1多态性与乳腺癌易感性之间的关联。根据纳入和排除标准筛选数据、提取数据，并评估纳入研究的质量。使用RevMan 5.2和Stata 12.0软件计算合并比值比（OR）及95%置信区间（95%CI）。还评估了发表偏倚和敏感性分析。
荟萃分析共纳入15项病例对照研究，涉及5176例病例和5890例对照。结果显示，在中国人群中，与GSTM1非缺失基因型个体相比，GSTM1缺失基因型个体患乳腺癌的风险显著增加（OR=1.34，95%CI=1.12-1.60，P=0.002）。按地区进行的亚组分析显示，在中国南方和北方人群中，GSTM1缺失基因型个体与乳腺癌风险增加显著相关（南方：OR=1.14，95%CI=1.01-1.28，P=0.03；北方：OR=2.65，95%CI=2.04-3.34，P<0.01）。
当前的荟萃分析表明，GSTM1多态性与中国人群乳腺癌易感性显著相关，且GSTM1缺陷可能增加乳腺癌风险。
