Kadoya Manabu, Nakamura Shinobu, Sugio Yuka, Hiraoka Hiroko, Kurita Megumi, Harada Ayumi, Matsumoto Mieko, Nakanishi Rieko, Sugiura Tetsutaro
Health Service Station, Eco Solutions Company, Panasonic Corporation, 1048 Kadoma, Kadoma City, Osaka 571-8686, Japan.
Sangyo Eiseigaku Zasshi. 2014;56(5):121-7. doi: 10.1539/sangyoeisei.b14004. Epub 2014 Jul 7.
Specific Health Examinations and Guidance (Tokutei kenko shinsa/Tokutei hoken shido) are provided for people over 40 years of age to reduce the incidence of metabolic syndrome (MetS). In the present study, we evaluated the importance of weight control in people below 40 years of age.
Male subjects (n = 877), aged 30 years, without MetS, were examined. Subjects were classified into 3 groups based on body mass index (BMI): non-obese (BMI < 22), pre-obese (22 ≤ BMI < 25), and obese (BMI ≥ 25). Cox proportional hazards regression analysis was performed for each group to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of MetS in individuals in their 40s on the basis of changes in their BMI, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, high-density lipoprotein, and triglyceride levels between 30 and 35 years of age. In addition, subjects were classified into 3 sub-groups based on changes in BMI: stable-decrease (BMI change < 1), slight increase (1 ≤ BMI increase<2), and increase (2 ≤ BMI increase). HRs for the 3 BMI change sub-groups for MetS were calculated for non-obese and pre-obese subjects.
There was a significant association between changes in BMI and the incidence of MetS for non-obese individuals in their 40s (HR: 2.80, 95% CI: 1.61-4.88) and pre-obese subjects (HR: 2.00, 95% CI: 1.44-2.77). There were also significant associations between the stable/decrease and increase (HR: 9.39, 95% CI: 1.52-57.70) sub-groups and MetS in the non-obese group, as well as for the slight increase (HR: 2.30, 95% CI: 1.03-5.11) and increase (HR: 10.13, 95% CI: 4.30-23.80) sub-groups in the pre-obese group.
BMI change in young adults is an important risk factor for MetS among individuals in their 40s. Even subjects with a BMI lower than 25 had differences in the risk of developing MetS based on their BMI change sub-group. In the field of occupational health, it will be necessary to promote stable weight control in young adults to reduce the incidence of MetS.
为40岁以上人群提供特定健康检查与指导（特定健康检查/特定保健指导），以降低代谢综合征（MetS）的发病率。在本研究中，我们评估了40岁以下人群体重控制的重要性。
对877名30岁无MetS的男性受试者进行检查。根据体重指数（BMI）将受试者分为3组：非肥胖（BMI<22）、超重（22≤BMI<25）和肥胖（BMI≥25）。对每组进行Cox比例风险回归分析，根据30至35岁期间BMI、收缩压、舒张压、空腹血糖、高密度脂蛋白和甘油三酯水平的变化，计算40多岁个体发生MetS的风险比（HRs）和第95百分位数置信区间（CIs）。此外，根据BMI变化将受试者分为3个亚组：稳定下降（BMI变化<1）、轻度增加（1≤BMI增加<2）和增加（2≤BMI增加）。计算非肥胖和超重受试者MetS的3个BMI变化亚组的HRs。
40多岁的非肥胖个体（HR：2.80，95%CI：1.61-4.88）和超重受试者（HR：2.00，95%CI：1.44-2.77）的BMI变化与MetS发病率之间存在显著关联。非肥胖组中稳定下降/下降和增加亚组（HR：9.39，95%CI：1.52-57.70）与MetS之间也存在显著关联，超重组中轻度增加（HR：2.30，95%CI：1.03-5.11）和增加亚组（HR：10.13，95%CI：4.30-23.80）与MetS之间也存在显著关联。
年轻人的BMI变化是40多岁个体发生MetS的重要危险因素。即使BMI低于25的受试者，根据其BMI变化亚组，发生MetS的风险也存在差异。在职业健康领域，有必要促进年轻人稳定控制体重，以降低MetS的发病率。
