Suzuki Akiko, Kosuge Keiichiro, Nanyu Osamu, Watanabe Hiroshi, Watanabe Toru, Usuda Yoshimaru, Sasaki Shigeru, Aizawa Yoshifusa
Division of Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
Intern Med. 2010;49(1):1-6. doi: 10.2169/internalmedicine.49.2689. Epub 2010 Jan 1.
The incidence of metabolic syndrome (MetS) has not been fully studied.
The data of 35,534 subjects who underwent a health examination both in 1996 and 2001 were analyzed. Since the waist circumference was not available, modified criteria of MetS was used for those with 3 or more of the following items: 1) body mass index (BMI) >or=25 kg/m(2), 2) blood pressure >or=130 mm Hg in systolic and/or >or=85 mm Hg in diastolic, 3) triglycerides >or=150 mg/dL, 4) high-density lipoprotein (HDL) cholesterol <or=40 mg/dL in men, <or=50 mg/dL in women, and 5) fasting blood glucose (FBG) >or=100 mg/dL. The subjects who underwent therapy for hypertension, diabetes mellitus, and high TG were considered to have these items. The incidence of MetS over 5 years was determined and its risks were evaluated by Cox proportional-hazards models. During the follow-up of exactly 5 years, MetS developed in 2,853 (9.32%) among 30,623 subjects who had no MetS at baseline. The subjects who developed MetS were older, and had elevated BMI, blood pressure, TG and FBG (p<0.001 for all) and lower HDL (p<0.034 for men and p<0.001 for women). Each item of MetS and their combination was associated with a higher risk to develop MetS. Obesity (BMI >or=25 kg/m(2)) alone or in combination with another item was associated with a higher risk to develop MetS suggesting it plays a key role.
MetS using BMI developed in 9.32% over 5 years or 1.86%/year. Each item of MetS or their combination showed a high risk to develop MetS. Obesity was associated with a higher hazard ratio to develop MetS.
代谢综合征（MetS）的发病率尚未得到充分研究。
对1996年和2001年接受健康检查的35534名受试者的数据进行了分析。由于腰围数据不可得，对于具有以下3项或更多项的受试者采用改良的MetS标准：1）体重指数（BMI）≥25 kg/m²，2）收缩压≥130 mmHg和/或舒张压≥85 mmHg，3）甘油三酯≥150 mg/dL，4）男性高密度脂蛋白（HDL）胆固醇≤40 mg/dL，女性≤50 mg/dL，5）空腹血糖（FBG）≥100 mg/dL。接受高血压、糖尿病和高甘油三酯治疗的受试者被认为具有这些指标。确定了5年期间MetS的发病率，并通过Cox比例风险模型评估其风险。在恰好5年的随访期间，30623名基线时无MetS的受试者中有2853名（9.32%）发生了MetS。发生MetS的受试者年龄较大，BMI、血压、甘油三酯和空腹血糖升高（所有p<0.001），HDL较低（男性p<0.034，女性p<0.001）。MetS的各项指标及其组合与发生MetS的较高风险相关。单独肥胖（BMI≥25 kg/m²）或与另一项指标组合与发生MetS的较高风险相关，表明其起关键作用。
使用BMI的MetS在5年期间发病率为9.32%，即每年1.86%。MetS的各项指标或其组合显示出发生MetS的高风险。肥胖与发生MetS的较高风险比相关。
