Yañez-Soto Bernardo, Mannis Mark J, Schwab Ivan R, Li Jennifer Y, Leonard Brian C, Abbott Nicholas L, Murphy Christopher J
Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA; Department of Chemical and Biological Engineering, School of Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Department of Ophthalmology & Vision Sciences, School of Medicine, University of California, Davis, Davis, CA.
Ocul Surf. 2014 Jul;12(3):178-201. doi: 10.1016/j.jtos.2014.01.004. Epub 2014 Apr 16.
Ocular surface disorders, such as dry eye disease, ocular rosacea, and allergic conjunctivitis, are a heterogeneous group of diseases that require an interdisciplinary approach to establish underlying causes and develop effective therapeutic strategies. These diverse disorders share a common thread in that they involve direct changes in ocular surface chemistry as well as the rheological properties of the tear film and topographical attributes of the cellular elements of the ocular surface. Knowledge of these properties is crucial to understand the formation and stability of the preocular tear film. The study of interfacial phenomena of the ocular surface flourished during the 1970s and 1980s, but after a series of lively debates in the literature concerning distinctions between the epithelial and the glandular origin of ocular surface disorders during the 1990s, research into this important topic has declined. In the meantime, new tools and techniques for the characterization and functionalization of biological surfaces have been developed. This review summarizes the available literature regarding the physicochemical attributes of the ocular surface, analyzes the role of interfacial phenomena in the pathobiology of ocular surface disease, identifies critical knowledge gaps concerning interfacial phenomena of the ocular surface, and discusses the opportunities for the exploitation of these phenomena to develop improved therapeutics for the treatment of ocular surface disorders.
眼表疾病，如干眼症、眼部酒渣鼻和过敏性结膜炎，是一组异质性疾病，需要采用跨学科方法来确定潜在病因并制定有效的治疗策略。这些不同的疾病有一个共同特点，即它们涉及眼表化学的直接变化以及泪膜的流变学特性和眼表细胞成分的地形学特征。了解这些特性对于理解眼前泪膜的形成和稳定性至关重要。眼表界面现象的研究在20世纪70年代和80年代蓬勃发展，但在20世纪90年代文献中就眼表疾病上皮起源和腺性起源之间的区别进行了一系列激烈辩论之后，对这一重要课题的研究有所下降。与此同时，已经开发出用于生物表面表征和功能化的新工具和技术。本综述总结了关于眼表物理化学特性的现有文献，分析了界面现象在眼表疾病病理生物学中的作用，确定了关于眼表界面现象的关键知识空白，并讨论了利用这些现象开发改进的眼表疾病治疗方法的机会。
